SCHEMBL1778231

SCHEMBL1778231

C=CCn1c(=O)c2[nH]c(-c3cc(OCC(=O)N4CCN(c5ccccc5)CC4)nn3C)nc2n(CC=C)c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ ADORA2B P29275 15/20 1.00
▸ ADORA1 P30542 9/20 0.81
▸ ADORA2A P29274 7/20 0.53
▸ ADORA3 P0DMS8 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5336024 0.91 ADORA2B (0.83) ADORA2BADORA1ADORA2AADORA3
SCHEMBL5334257 0.90 ADORA2B (0.82) ADORA2BADORA1ADORA2AADORA3
SCHEMBL14517865 0.90 ADORA2B (0.82) ADORA2BADORA1ADORA2AADORA3
SCHEMBL1780657 0.89 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL4759172 0.85 ADORA2B (0.73) ADORA2BADORA1ADORA2AADORA3
SCHEMBL1569329 0.84 ADORA2B (0.89) ADORA2BADORA1ADORA2A
SCHEMBL1780628 0.82 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL14267751 0.80 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL1779738 0.79 ADORA2B (1.00) ADORA2BADORA1ADORA2A
SCHEMBL14267752 0.78 ADORA2B (0.64) ADORA2BADORA1ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4626494-A1 LYOPHILIZED AND SPRAYABLE SILK FIBROIN AND MODIFIED SILK FIBROIN FORMS Evolved by Nature, Inc. (US) 2025-10-08 — — EP claimed
EP-4587635-A2 FIBROIN PEPTIDES AND PROTEIN FRAGMENTS COMPOSITIONS Evolved by Nature, Inc. (US) 2025-07-23 — — EP claimed
WO-2024059862-A9 FIBROIN PEPTIDES AND PROTEIN FRAGMENTS COMPOSITIONS EVOLVED BY NATURE, INC. (US) 2025-04-24 — — WO claimed
WO-2024119107-A1 LYOPHILIZED AND SPRAYABLE SILK FIBROIN AND MODIFIED SILK FIBROIN FORMS EVOLVED BY NATURE, INC. (US) 2024-06-06 — — WO claimed
WO-2024059862-A2 FIBROIN PEPTIDES AND PROTEIN FRAGMENTS COMPOSITIONS EVOLVED BY NATURE, INC. (US) 2024-03-21 — — WO claimed
US-20110118276-A1 METHODS OF TREATING ATHEROSCLEROSIS KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT INC 2011-05-19 — — US claimed
US-7335655-B2 8-heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2008-02-26 — — US claimed
US-7205403-B2 8-Heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2007-04-17 — — US claimed
US-20060142309-A1 8-Heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. 2006-06-29 — — US claimed
US-20030207879-A1 8-Heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. 2003-11-06 — — US claimed
EP-4703470-A1 CELLULASE VARIANTS AB Enzymes Finland Oy (FI) 2026-03-04 — — EP disclosed
EP-4626494-A1 LYOPHILIZED AND SPRAYABLE SILK FIBROIN AND MODIFIED SILK FIBROIN FORMS Evolved by Nature, Inc. (US) 2025-10-08 — — EP disclosed
US-20250277211-A1 LPA inhibitors and uses thereof KYLONOVA XIAMEN BIOPHARMA CO LTD (CN) 2025-09-04 — — US disclosed
EP-4610356-A1 RNA INHIBITOR FOR INHIBITING LPA GENE EXPRESSION AND USE THEREOF Kylonova (Xiamen) Biopharma Co., Ltd. (CN) 2025-09-03 — — EP disclosed
EP-4587635-A2 FIBROIN PEPTIDES AND PROTEIN FRAGMENTS COMPOSITIONS Evolved by Nature, Inc. (US) 2025-07-23 — — EP disclosed
US-7335655-B2 8-heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2008-02-26 — — US disclosed
US-7335655-B2 8-heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2008-02-26 — — US disclosed
US-7205403-B2 8-Heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2007-04-17 — — US disclosed
US-7205403-B2 8-Heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. (US) 2007-04-17 — — US disclosed
US-20060142309-A1 8-Heteroaryl xanthine adenosine A2B receptor antagonists KING PHARMACEUTICALS RESEARCH AND DEVELOPMENT, INC. 2006-06-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110118276-A1 METHODS OF TREATING ATHEROSCLEROSIS ADORA2B, ADORA2A, ADORA3 ADORA2B 1/4885ADORA1 4/4885ADORA2A 2/4885
US-20030207879-A1 8-Heteroaryl xanthine adenosine A2B receptor antagonists ADORA2B, ADORA2A, ADORA1 ADORA2B 1/4885ADORA1 3/4885ADORA2A 2/4885
US-20060142309-A1 8-Heteroaryl xanthine adenosine A2B receptor antagonists ADORA2B, ADORA2A, ADORA1 ADORA2B 1/4885ADORA1 3/4885ADORA2A 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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