Sugi Predict

Sugi Predict / Compounds / SCHEMBL145182

SCHEMBL145182

SCHEMBL145182

Cc1c(Br)ccc(N)c1N

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.39
▸ CYP3A4 P08684 5/20 0.39
▸ TSHR P16473 3/20 0.39
▸ TDP1 Q9NUW8 3/20 0.39
▸ CD44 P16070 1/20 0.39
▸ PIK3CA P42336 1/20 0.38
▸ TP53 P04637 1/20 0.35
▸ THRB P10828 1/20 0.35
▸ ALOX15 P16050 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ AXL P30530 1/20 0.34
▸ MAPT P10636 3/20 0.33
▸ POLB P06746 3/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ L3MBTL1 Q9Y468 2/20 0.33
▸ HTT P42858 1/20 0.33
▸ APAF1 O14727 1/20 0.32
▸ TDP2 O95551 1/20 0.32
▸ CASP3 P42574 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29901155 1.00 ALDH1A1 (0.39) ALDH1A1CYP3A4TSHRTDP1CD44
SCHEMBL580651 0.81 CYP3A4 (0.46) ALDH1A1CYP3A4TSHRTDP1PIK3CA
SCHEMBL29863836 0.79 POLB (0.56) ALDH1A1CYP3A4TSHRTDP1CD44
SCHEMBL2319989 0.79 ALDH1A1 (0.39) ALDH1A1CYP3A4TSHRTDP1PIK3CA
SCHEMBL1198842 0.79 POLB (0.56) ALDH1A1CYP3A4TSHRTDP1CD44
SCHEMBL30238695 0.79 ALDH1A1 (0.42) ALDH1A1CYP3A4TSHRTDP1PIK3CA
SCHEMBL29870911 0.77 CYP3A4 (0.53) ALDH1A1CYP3A4TSHRTDP1CD44
SCHEMBL2934547 0.77 CYP3A4 (0.53) ALDH1A1CYP3A4TSHRTDP1CD44
SCHEMBL23153960 0.75 CYP3A4 (0.36) ALDH1A1CYP3A4TSHRTDP1PIK3CA
SCHEMBL10989330 0.75 ALDH1A1 (0.38) ALDH1A1CYP3A4TSHRTDP1CD44

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116122057-A High-strength cold-resistant textile for aerospace use and manufacturing method thereof 西京学院 2023-05-16 — — CN claimed
EP-4452256-B1 METHODS OF TREATING BRAIN TUMOURS AND NEUROBLASTOMAS ASTRAZENECA AB (SE) 2025-12-10 — — EP disclosed
US-20250368615-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB (SE) 2025-12-04 — — US disclosed
US-12421208-B2 Chemical compounds ASTRAZENECA AB (SE) 2025-09-23 — — US disclosed
WO-2025101780-A1 PHARMACOLOGICAL CORRECTORS OF RHODOPSIN AND USES THEREOF OCTANT, INC. (US) 2025-05-15 — — WO disclosed
US-20250082630-A1 METHODS OF TREATING BRAIN TUMOURS AND NEUROBLASTOMAS ASTRAZENECA AB (SE) 2025-03-13 — — US disclosed
CN-118317793-A Methods for treating brain tumors and neuroblastomas 阿斯利康(瑞典)有限公司 2024-07-09 — — CN disclosed
US-20240109900-A1 AZABICYCLIC SHP2 INHIBITORS PROMIDIS S.R.L. (IT) 2024-04-04 — — US disclosed
EP-3906233-B1 KINASE INHIBITOR COMPOUNDS AND COMPOSITIONS AND METHODS OF USE ICAHN SCHOOL MED MOUNT SINAI (US) 2024-01-31 — — EP disclosed
US-20240010631-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB (SE) 2024-01-11 — — US disclosed
US-7678820-B2 Hetero compound ASTELLAS PHARMA INC. (JP) 2010-03-16 — — US disclosed
EP-1426392-B1 COMPOSITION FOR OPTICAL MATERIAL MITSUBISHI GAS CHEMICAL CO (JP) 2010-02-24 — — EP disclosed
EP-2049481-A2 NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS SmithKline Beecham Corporation (US) 2009-04-22 — — EP disclosed
US-20090076070-A1 HETERO COMPOUND ASTELLAS PHARMA INC. (JP) 2009-03-19 — — US disclosed
US-20090076070-A1 HETERO COMPOUND ASTELLAS PHARMA INC. (JP) 2009-03-19 — — US disclosed
WO-2008021851-A2 NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS SMITHKLINE BEECHAM CORPORATION (US) 2008-02-21 — — WO disclosed
WO-2008021851-A2 NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS FOR OPIOID RECEPTORS SMITHKLINE BEECHAM CORPORATION (US) 2008-02-21 — — WO disclosed
US-6960640-B2 Composition for optical material MITSUBISHI GAS CHEMICAL CO., LTD. (JP) 2005-11-01 — — US disclosed
US-20040147708-A1 Composition for optical material MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-07-29 — — US disclosed
EP-1426392-A1 COMPOSITION FOR OPTICAL MATERIAL MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2004-06-09 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240010631-A1 CHEMICAL COMPOUNDS CYP11B2, CYP11B1, CYP4B1 ALDH1A1 123/4885CYP3A4 11/4885TSHR 4456/4885
US-20240109900-A1 AZABICYCLIC SHP2 INHIBITORS PTPN22, PTPN2, PTPN5 ALDH1A1 3046/4885CYP3A4 4644/4885TSHR 2166/4885
US-20250368615-A1 CHEMICAL COMPOUNDS CYP11B2, CYP11B1, CYP4B1 ALDH1A1 123/4885CYP3A4 11/4885TSHR 4456/4885
US-12421208-B2 Chemical compounds CYP11B2, CYP11B1, CYP4B1 ALDH1A1 123/4885CYP3A4 11/4885TSHR 4456/4885
US-20250082630-A1 METHODS OF TREATING BRAIN TUMOURS AND NEUROBLASTOMAS PARP1, PARP2, PARP3 ALDH1A1 1557/4885CYP3A4 3500/4885TSHR 3485/4885
US-20090076070-A1 HETERO COMPOUND S1PR1, ENPP2, LPAR1 ALDH1A1 3640/4885CYP3A4 2863/4885TSHR 2076/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.