Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 13/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 2/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6752581 | 0.77 | PDE4A (0.58) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| SCHEMBL6751869 | 0.76 | POLB (0.47) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| Hydrochloric Acid SCHEMBL5490684 | 0.76 | TOP2A (0.45) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| Hydrochloric Acid SCHEMBL5418438 | 0.75 | POLB (0.46) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| Hydrochloric Acid SCHEMBL5431184 | 0.72 | PDE4A (0.39) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| Hydrochloric Acid SCHEMBL5431175 | 0.70 | PDE4A (0.39) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| SCHEMBL6753019 | 0.69 | ESR1 (0.36) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| SCHEMBL5142092 | 0.69 | NQO2 (0.57) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| SCHEMBL23566023 | 0.67 | NQO2 (0.55) | NQO2ALDH1A1HPGDHSD17B10PRMT1 | |
| Hydrochloric Acid SCHEMBL3363452 | 0.67 | TOP2A (0.58) | NQO2ALDH1A1HPGDHSD17B10PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070088067-A1 | Novel amidine compounds for treating microbial infections | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2007-04-19 | — | — | US | disclosed |
| US-20070088067-A1 | Novel amidine compounds for treating microbial infections | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2007-04-19 | — | — | US | disclosed |
| US-20070021483-A1 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-01-25 | — | — | US | disclosed |
| US-20070021483-A1 | Amidine derivatives for treating amyloidosis | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088067-A1 | Novel amidine compounds for treating microbial infections | ARG1, ARG2, GSDMD | NQO2 1427/4885ALDH1A1 4418/4885HPGD 1569/4885 |
| US-20070021483-A1 | Amidine derivatives for treating amyloidosis | APP, IAPP, GRN | NQO2 205/4885ALDH1A1 2283/4885HPGD 1256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.