GSDMD

Gasdermin-D · P57764 · GSDMD on Sugi Atlas →

1,235 patent compounds predicted against GSDMD, 640 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Disulfiram (SCHEMBL27213)	1.00	2/20
Disulfiram (SCHEMBL4654748)	1.00	2/20
Disulfiram (SCHEMBL5364281)	0.94	2/20
Disulfiram (SCHEMBL5961375)	0.94	2/20
Disulfiram (SCHEMBL10886601)	0.94	2/20
Disulfiram (SCHEMBL11155542)	0.94	2/20
Disulfiram (SCHEMBL28074264)	0.94	2/20
Disulfiram (SCHEMBL28246322)	0.94	2/20
Disulfiram (SCHEMBL28867973)	0.94	2/20
Ditiocarb (SCHEMBL80288)	0.94	2/20
Ditiocarb (SCHEMBL81092)	0.94	2/20
Ditiocarb (SCHEMBL452142)	0.94	2/20
Ditiocarb (SCHEMBL1395953)	0.94	2/20
Ditiocarb (SCHEMBL2234902)	0.94	2/20
Ditiocarb (SCHEMBL9700626)	0.94	2/20
Ditiocarb (SCHEMBL21359739)	0.94	2/20
Ditiocarb (SCHEMBL25284941)	0.94	2/20
Ditiocarb (SCHEMBL28803715)	0.94	2/20
Disulfiram (SCHEMBL4734237)	0.89	2/20
Disulfiram (SCHEMBL10542872)	0.89	2/20

Clinical trials — most relevant to GSDMD by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
Efficacy and Safety of Empagliflozin in GSD-Ib Patients	PHASE2	WITHDRAWN
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
New Signaling Pathway Targeting Systemic Lupus Erythematosus	nan	UNKNOWN
The Role of Pyroptosis in Chronic Venous Disease	nan	UNKNOWN
Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases	nan	UNKNOWN
Early Diagnosis and Prognosis of Postoperative Sepsis by Presepsin and Syndecan-1	nan	UNKNOWN
Inflammasomes in Cell Death in FTMH, ERM, and RRD	nan	COMPLETED
Role of Type 2 Diabetes in Potentiating the Inflammatory Response Post Extracorporeal Circulation After Cardiac Surgery	nan	WITHDRAWN
Caspase-1 Activity, IL-1beta, and IL-18 in Patients With FMF	nan	NOT_YET_RECRUITING
Probiotics and Systemic Inflammation in Patients With Metabolic Syndrome and High Cardiovascular Risk	nan	WITHDRAWN
Gluten-related Disorders in Familial Mediterranean Fever Patients	nan	COMPLETED
The T Cell Activator of Cell Killing (TACK) IT ON STUDY	nan	RECRUITING
The Mechanisms and Significances of Synergistic Effects of Mycophenolic Acid and LPS on IL-1β Secretion by Mononuclear	nan	UNKNOWN
Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients	nan	UNKNOWN
Decoding the Genetic Landscape of Skeletal Diseases	nan	RECRUITING
Extremes of Coronary Artery Disease and Normality:CAD Extremes	nan	RECRUITING
Genome Analysis of Human Endogenous Retroviruses (HERVs)(COVID19)	nan	RECRUITING
Natural History, Pathogenesis, and Outcome of Autoinflammatory Diseases (NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still'S-like Diseases, and Other Undifferentiated Autoinflammatory Diseases)	nan	RECRUITING
Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients	nan	COMPLETED
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis	nan	COMPLETED
RNA Cloning and Visualization in Human Atherosclerosis	nan	COMPLETED
Macrolide Mediates Pulmonary Infection of Pseudomonas Aeruginosa	nan	COMPLETED
Pathogenic Mechanisms in C Diff Infection and Colitis	nan	COMPLETED
Omega-3 to Reduce Diabetes Risk in Subjects With High Number of Particles That Carry Bad Cholesterol in the Blood	nan	COMPLETED
Kinetics of Nasal Cytokine Responses to Mechanical Stimulation	nan	COMPLETED
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Biomarker for Glycogen Storage Diseases (BioGlycogen)	nan	WITHDRAWN
Role NLRP3 Inflammasome in Weight Loss Following Sleeve Gastrectomy in Morbidly Obese Patients	nan	UNKNOWN
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a GSDMD binder may also engage these)

Protein	Name	Similarity
Q9D8T2	—	0.997	Q9D8T2 →
Q8CB12	—	0.990	Q8CB12 →
P85967	—	0.990	P85967 →
Q96QA5	—	0.990	Q96QA5 →
Q5Y4Y6	—	0.989	Q5Y4Y6 →
Q99NB5	—	0.988	Q99NB5 →
Q32M21	—	0.988	Q32M21 →
Q9BYG8	—	0.986	Q9BYG8 →
Q3TR54	—	0.986	Q3TR54 →
Q9EST1	—	0.985	Q9EST1 →
Q2KHK6	—	0.984	Q2KHK6 →
Q6PDZ2	—	0.983	Q6PDZ2 →
Q8TAX9	—	0.981	Q8TAX9 →
Q80VA5	—	0.981	Q80VA5 →
Q8CIE4	—	0.980	Q8CIE4 →
Q15572	—	0.980	Q15572 →
Q8K330	—	0.978	Q8K330 →
A1L3T7	—	0.978	A1L3T7 →
Q9EQR6	—	0.978	Q9EQR6 →
A0A8I3PMN2	—	0.978	A0A8I3PMN2 →
Q8CFK6	—	0.977	Q8CFK6 →
P70434	—	0.977	P70434 →
Q8BHW9	—	0.977	Q8BHW9 →
P33076	—	0.977	P33076 →
Q5PNP6	—	0.977	Q5PNP6 →
Q5EE38	—	0.977	Q5EE38 →
Q9HB65	—	0.976	Q9HB65 →
Q5T124	—	0.976	Q5T124 →
Q8BLY7	—	0.976	Q8BLY7 →
Q3U0V2	—	0.976	Q3U0V2 →