Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 11/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14500619 | 0.93 | CDK9 (0.48) | CDK9CCNT1TBK1JAK1CNR1 | |
| SCHEMBL13994232 | 0.90 | TBK1 (0.51) | CDK9CCNT1TBK1JAK1PRKCQ | |
| SCHEMBL14520516 | 0.90 | CDK9 (0.48) | CDK9CCNT1TBK1JAK1CNR1 | |
| SCHEMBL5001675 | 0.86 | CCNT1 (0.49) | CDK9CCNT1TBK1JAK1CNR1 | |
| SCHEMBL5001788 | 0.82 | CDK9 (0.48) | CDK9CCNT1TBK1JAK1CNR1 | |
| SCHEMBL14530722 | 0.82 | EGFR (0.39) | CDK9CCNT1PRKCQ | |
| SCHEMBL14520514 | 0.82 | CCNT1 (0.43) | CDK9CCNT1PRKCQ | |
| SCHEMBL14500618 | 0.81 | CCNT1 (0.40) | CDK9CCNT1PRKCQ | |
| SCHEMBL5005478 | 0.81 | TBK1 (0.51) | CDK9CCNT1TBK1JAK1PRKCQ | |
| SCHEMBL14531051 | 0.78 | CCNT1 (0.40) | CDK9CCNT1PRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007067537-A1 | PYRROLOPYRIDINE KINASE INHIBITING COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |