Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 4/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.53 |
| ▸ | ATR | Q13535 | 1/20 | 0.51 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14527434 | 0.86 | GHSR (0.53) | GHSRHDAC6KDM4EALDH1A1HPGD | |
| SCHEMBL14527422 | 0.84 | CHEK2 (0.49) | KDM4EALDH1A1HPGDENPP2HSD17B10 | |
| SCHEMBL14526878 | 0.79 | KDM4E (0.63) | GHSRHDAC6KDM4EALDH1A1HPGD | |
| SCHEMBL14082569 | 0.79 | ATR (0.65) | MKNK1MKNK2ATRCYP11B1CYP11B2 | |
| SCHEMBL7497614 | 0.79 | FGFR1 (0.62) | GHSRATRCYP19A1CYP11B1CYP11B2 | |
| SCHEMBL14526879 | 0.78 | NPC1 (0.71) | MKNK1MKNK2DEGS1ALDH1A1LMNA | |
| SCHEMBL8770566 | 0.76 | MAPT (0.70) | ATRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL14527318 | 0.75 | MKNK1 (0.66) | MKNK1MKNK2DEGS1CYP11B1CYP11B2 | |
| SCHEMBL14527309 | 0.75 | MKNK1 (0.66) | MKNK1MKNK2DEGS1CYP11B1CYP11B2 | |
| SCHEMBL14527311 | 0.75 | MKNK1 (0.66) | MKNK1MKNK2DEGS1CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070093529-A1 | Diacylhydrazine derivatives | MERCK PATENT GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
| US-20070093529-A1 | Diacylhydrazine derivatives | MERCK PATENT GMBH (DE) | 2007-04-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093529-A1 | Diacylhydrazine derivatives | BRAF, RAF1, NRAS | GHSR 3536/4885MKNK1 224/4885MKNK2 240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.