Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.62 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.57 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.57 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.57 |
| ▸ | QPCT | Q16769 | 1/20 | 0.56 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | GHSR | Q92847 | 1/20 | 0.49 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.49 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.49 |
| ▸ | ATR | Q13535 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | CCNC | P24863 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6657347 | 0.87 | NPC1 (0.64) | FGFR1CYP11B2CYP11B1CYP19A1CYP17A1 | |
| SCHEMBL1423263 | 0.82 | NPC1 (0.66) | ALDH1A1 | |
| Ethyl Propionate SCHEMBL27742094 | 0.82 | MMP2 (0.54) | FGFR1CYP11B2CYP11B1CYP19A1CYP1A2 | |
| SCHEMBL14527403 | 0.79 | GHSR (0.56) | CYP11B2CYP11B1CYP19A1ALDH1A1GHSR | |
| SCHEMBL18000228 | 0.79 | BRAF (0.58) | CYP11B2CYP11B1CYP17A1GHSRPIP4K2A | |
| SCHEMBL30253604 | 0.78 | NPC1 (0.71) | FGFR1ALDH1A1CYP2A6GHSRPIP4K2A | |
| SCHEMBL443799 | 0.78 | NPC1 (0.71) | FGFR1ALDH1A1CYP2A6GHSRPIP4K2A | |
| SCHEMBL26260198 | 0.78 | CYP11B2 (0.88) | FGFR1CYP11B2CYP11B1CYP19A1CYP17A1 | |
| SCHEMBL17067225 | 0.78 | FGFR1 (0.59) | FGFR1CYP11B2CYP11B1CYP19A1CYP17A1 | |
| SCHEMBL16935421 | 0.77 | FGFR1 (1.00) | FGFR1CYP11B2CYP11B1CYP19A1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734386-B1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | ABBOTT LAB (US) | 2002-02-06 | — | — | EP | disclosed |
| EP-0595924-B1 | PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LAB (US) | 1999-04-14 | — | — | EP | disclosed |
| US-5643922-A | Indole cyclohexyl platelet activating factor antagonists | ABBOTT LABORATORIES (US) | 1997-07-01 | — | — | US | disclosed |
| EP-0734386-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | Abbott Laboratories (US) | 1996-10-02 | — | — | EP | disclosed |
| US-5486525-A | ANTIINFLAMMATORY AGENTS | ABBOTT LABORATORIES (US) | 1996-01-23 | — | — | US | disclosed |
| US-5459152-A | 3-(pyridin-3-yl)-7-(indol-3-yl)carbonyl-1H,3H-pyrrolo(1,2-c) thiazole derivatives; asthma | ABBOTT LABORATORIES (US) | 1995-10-17 | — | — | US | disclosed |
| WO-1995016687-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS: IMIDAZOPYRIDINE INDOLES | ABBOTT LABORATORIES (US) | 1995-06-22 | — | — | WO | disclosed |
| EP-0595924-A4 | PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LAB (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0595924-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1994-05-11 | — | — | EP | disclosed |
| WO-1993001813-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1993-02-04 | — | — | WO | disclosed |