Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 5/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23232595 | 0.86 | MAPK1 (0.50) | MAPK1ALDH1A1MAOBMAOAFABP4 | |
| SCHEMBL22299331 | 0.75 | CHRM2 (0.54) | MAPK1ALDH1A1MAOBFABP4RAB9A | |
| SCHEMBL14528680 | 0.73 | FABP4 (0.55) | MAPK1ALDH1A1MAOBMAOAFABP4 | |
| SCHEMBL115115 | 0.73 | ALDH1A1 (1.00) | MAPK1ALDH1A1RAB9ATP53MAPT | |
| SCHEMBL30451936 | 0.73 | ALDH1A1 (1.00) | MAPK1ALDH1A1RAB9ATP53MAPT | |
| SCHEMBL2149631 | 0.72 | MAOB (0.76) | MAPK1ALDH1A1MAOBMAOARAB9A | |
| SCHEMBL10337819 | 0.71 | HSD17B10 (0.48) | ALDH1A1FABP4RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL14528516 | 0.71 | FABP4 (0.60) | FABP4TSHRF2F10PLG | |
| Water SCHEMBL2802174 | 0.71 | ALDH1A1 (0.94) | MAPK1ALDH1A1RAB9ATP53MAPT | |
| Methane SCHEMBL10434104 | 0.71 | ALDH1A1 (0.94) | MAPK1ALDH1A1RAB9ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181014-B1 | HETEROCYCLIC CONTAINING BIPHENYL aP2 INHIBITORS AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2007-05-23 | — | — | EP | disclosed |