Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 5/20 | 0.42 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2922149 | 0.81 | RAB9A (0.52) | RAB9ANPC1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL14528682 | 0.81 | FABP4 (0.65) | FABP4RAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL14528516 | 0.79 | FABP4 (0.60) | FABP4TSHRCNR2KDRFYN | |
| SCHEMBL14528510 | 0.78 | FABP4 (0.55) | FABP4RAB9ANPC1MAOBKMT2A | |
| SCHEMBL9876129 | 0.77 | CNR2 (0.51) | RAB9ANPC1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL28414965 | 0.77 | ACHE (0.55) | RAB9ANPC1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL14528686 | 0.76 | FABP4 (0.53) | FABP4RAB9AGSK3BMMP9KMT2A | |
| SCHEMBL24689747 | 0.75 | ACHE (0.52) | RAB9ANPC1HPGDTSHRSMN1; SMN2 | |
| SCHEMBL14528474 | 0.73 | MAPK1 (0.55) | FABP4RAB9ANPC1HPGDTSHR | |
| SCHEMBL12968446 | 0.72 | SMN1; SMN2 (0.49) | RAB9ANPC1HPGDTSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181014-B1 | HETEROCYCLIC CONTAINING BIPHENYL aP2 INHIBITORS AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2007-05-23 | — | — | EP | disclosed |