Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26064187 | 0.89 | HRH3 (0.37) | HRH3KCNH2CHRM2CHRM4CHRM1 | |
| SCHEMBL14529148 | 0.80 | ALDH1A1 (0.38) | HRH3KCNH2ALDH1A1PKMKDM4E | |
| SCHEMBL14528916 | 0.79 | ADRA1A (0.32) | ADRA1A | |
| SCHEMBL14528912 | 0.79 | ADRA1A (0.32) | ADRA1A | |
| SCHEMBL1158423 | 0.75 | CHRM1 (0.38) | HRH3ALDH1A1KDM4ECHRM2CHRM4 | |
| SCHEMBL14528540 | 0.74 | ADRA1A (0.32) | HRH3ADRA1A | |
| SCHEMBL14528889 | 0.74 | NAAA (0.46) | HRH3ALDH1A1CHRM2CHRM4CHRM1 | |
| SCHEMBL15806952 | 0.73 | MAP3K12 (0.33) | HRH3CHRM1 | |
| SCHEMBL10191388 | 0.73 | KCNH2 (0.33) | HRH3KCNH2ALDH1A1PKMKDM4E | |
| SCHEMBL12835 | 0.73 | KCNH2 (0.33) | HRH3KCNH2ALDH1A1PKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053498-A1 | COMPOUNDS USEFUL AS ANTAGONISTS OF CCR2 | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-05-10 | — | — | WO | disclosed |