Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.72 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315520 | 0.84 | SIGMAR1 (1.00) | SIGMAR1ADRA2A | |
| SCHEMBL30623345 | 0.84 | SIGMAR1 (1.00) | SIGMAR1ADRA2A | |
| SCHEMBL4975673 | 0.73 | SIGMAR1 (0.54) | SIGMAR1KCNH2 | |
| SCHEMBL14530282 | 0.73 | SIGMAR1 (0.40) | SIGMAR1OPRD1KCNH2GRIN2B | |
| SCHEMBL11860423 | 0.70 | SIGMAR1 (0.54) | SIGMAR1OPRD1KCNH2ADRA2A | |
| SCHEMBL14529908 | 0.67 | SIGMAR1 (0.48) | SIGMAR1ADRA2A | |
| SCHEMBL25358883 | 0.67 | SIGMAR1 (0.74) | SIGMAR1OPRD1ADRA2A | |
| SCHEMBL5312189 | 0.66 | SIGMAR1 (0.49) | SIGMAR1OPRD1 | |
| SCHEMBL11074758 | 0.65 | SIGMAR1 (0.46) | SIGMAR1OPRD1 | |
| SCHEMBL25358545 | 0.65 | SIGMAR1 (0.70) | SIGMAR1OPRD1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007057775-A1 | SPIROPIPERIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-05-24 | — | — | WO | disclosed |