Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | EBP | Q15125 | 1/20 | 0.57 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315520 | 1.00 | SIGMAR1 (1.00) | SIGMAR1ADRA2AOPRM1OPRK1EBP | |
| SCHEMBL25358883 | 0.85 | SIGMAR1 (0.74) | SIGMAR1ADRA2AOPRM1OPRK1EBP | |
| SCHEMBL14529832 | 0.84 | SIGMAR1 (0.72) | SIGMAR1ADRA2A | |
| SCHEMBL25358545 | 0.83 | SIGMAR1 (0.70) | SIGMAR1ADRA2AOPRM1OPRK1EBP | |
| SCHEMBL3019948 | 0.78 | SIGMAR1 (0.75) | SIGMAR1 | |
| SCHEMBL14530329 | 0.77 | SIGMAR1 (0.63) | SIGMAR1ADRA2AOPRM1OPRK1EBP | |
| SCHEMBL2360468 | 0.77 | SIGMAR1 (0.72) | SIGMAR1ADRA2AOPRM1OPRK1EBP | |
| SCHEMBL2360466 | 0.77 | SIGMAR1 (0.72) | SIGMAR1ADRA2AOPRM1OPRK1EBP | |
| SCHEMBL3403111 | 0.77 | SIGMAR1 (0.72) | SIGMAR1ADRA2AOPRM1OPRK1EBP | |
| SCHEMBL25358487 | 0.76 | SIGMAR1 (1.00) | SIGMAR1ADRA2AOPRM1OPRK1SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4476207-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | Vertex Pharmaceuticals Incorporated (US) | 2024-12-18 | — | — | EP | disclosed |
| WO-2023154314-A1 | SPIRO PIPERIDINE DERIVATIVES AS INHIBITORS OF APOL1 AND METHODS OF USING SAME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-08-17 | — | — | WO | disclosed |