Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 13/20 | 0.48 |
| ▸ | TTK | P33981 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8429700 | 0.78 | AURKA (0.63) | ADORA3FLT3AURKAAURKB | |
| SCHEMBL8246569 | 0.73 | AURKA (0.61) | ADORA3TTKFLT3AURKAAURKB | |
| SCHEMBL14538353 | 0.73 | TTK (0.46) | ADORA3TTKFLT3BRD4ATAD2 | |
| SCHEMBL8426757 | 0.72 | CHRNB2 (0.37) | ADORA3TTKFLT3AURKAAURKB | |
| SCHEMBL14533966 | 0.71 | AURKA (0.37) | ADORA3AURKAAURKB | |
| SCHEMBL14534093 | 0.71 | AURKA (0.53) | ADORA3FLT3AURKAAURKB | |
| SCHEMBL8426673 | 0.70 | AURKA (0.56) | ADORA3AURKAAURKB | |
| SCHEMBL8427933 | 0.70 | ZAP70 (0.35) | ADORA3TTKFLT3AURKA | |
| SCHEMBL8427761 | 0.69 | AURKA (0.36) | ADORA3AURKAAURKB | |
| SCHEMBL14534027 | 0.69 | AHCY (0.30) | ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058873-A2 | IMIDAZOPYRAZINES AS CYCLIN DEPENTEND KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |