Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 11/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.44 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8246569 | 0.80 | AURKA (0.61) | TTKADORA3FLT3AURKAAURKB | |
| SCHEMBL14536961 | 0.75 | FLT3 (0.51) | TTKADORA3FLT3 | |
| SCHEMBL8240997 | 0.75 | AURKB (0.57) | TTKAURKAAURKBIRAK4 | |
| SCHEMBL14529900 | 0.73 | TTK (0.50) | TTKFLT3AURKAAURKB | |
| SCHEMBL14530388 | 0.73 | ADORA3 (0.48) | TTKADORA3FLT3AURKAAURKB | |
| SCHEMBL14537080 | 0.71 | AURKA (0.45) | TTKADORA3FLT3AURKAAURKB | |
| SCHEMBL14507206 | 0.71 | TTK (0.41) | TTKFLT3AURKAAURKB | |
| SCHEMBL11940635 | 0.70 | ADORA3 (0.56) | TTKADORA3 | |
| SCHEMBL14529892 | 0.70 | TTK (0.47) | TTKADORA3AURKAAURKBIRAK4 | |
| SCHEMBL14530155 | 0.69 | AURKA (0.43) | TTKADORA3FLT3AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058942-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |