Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.71 |
| ▸ | BCR | P11274 | 5/20 | 0.71 |
| ▸ | SRC | P12931 | 2/20 | 0.71 |
| ▸ | EGFR | P00533 | 1/20 | 0.71 |
| ▸ | PRKACA | P17612 | 1/20 | 0.71 |
| ▸ | PRKACG | P22612 | 1/20 | 0.71 |
| ▸ | PRKACB | P22694 | 1/20 | 0.71 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.70 |
| ▸ | PLK1 | P53350 | 3/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.60 |
| ▸ | CDK4 | P11802 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | PRKCA | P17252 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL823915 | 0.91 | CAMK2D (0.82) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL4386919 | 0.87 | ABL1 (0.82) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL14530851 | 0.85 | PLK1 (0.75) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL27444270 | 0.84 | PLK1 (0.78) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL2944432 | 0.84 | ABL1 (0.82) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL1465 | 0.83 | ABL1 (1.00) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL1789 | 0.83 | ABL1 (1.00) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL2945644 | 0.82 | PLK1 (0.79) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL12801709 | 0.82 | CAMK2D (1.00) | ABL1BCRSRCEGFRPRKACA | |
| SCHEMBL3012944 | 0.81 | ABL1 (0.70) | ABL1BCRSRCEGFRPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007500179-A | — | — | 2007-01-11 | — | — | JP | claimed |
| EP-1648875-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | claimed |
| WO-2005012262-A1 | 2-AMINOPHENYL-4-PHENYLPYRIMIDINES AS KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | claimed |