Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 8/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SCN1A | P35498 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11929932 | 0.76 | ABHD6 (0.63) | EPHX2HRH3MAPK1ALDH1A1CYP1A2 | |
| SCHEMBL5481141 | 0.73 | EPHX2 (0.46) | EPHX2HRH3MAPK1ALDH1A1CYP1A2 | |
| SCHEMBL11929929 | 0.71 | ABHD6 (0.70) | HRH3ALDH1A1 | |
| SCHEMBL5480120 | 0.71 | HRH3 (0.50) | EPHX2HRH3MAPK1ALDH1A1CYP1A2 | |
| SCHEMBL14959462 | 0.70 | ABHD6 (0.64) | EPHX2HRH3SLC6A4MAPK1ALDH1A1 | |
| SCHEMBL6080084 | 0.70 | HRH3 (0.62) | EPHX2HRH3MAPK1ALDH1A1CYP1A2 | |
| SCHEMBL6195663 | 0.70 | HRH3 (0.61) | EPHX2HRH3MAPK1ALDH1A1CYP1A2 | |
| SCHEMBL13949485 | 0.69 | EPHX2 (0.67) | EPHX2HRH3MAPK1ALDH1A1CYP1A2 | |
| SCHEMBL6109975 | 0.68 | HRH3 (0.58) | HRH3 | |
| SCHEMBL4256695 | 0.68 | EPHX2 (0.74) | EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070105851-A1 | Indolyl-thienopyrazinone derivatives useful for treating hyperproliferative disorders and diseases associated with angiogenesis | BAYER PHARMACEUTICALS CORPORATION (US) | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105851-A1 | Indolyl-thienopyrazinone derivatives useful for treating hyperproliferative disorders and diseases associated with angiogenesis | MKI67, CDK4, PGF | EPHX2 3480/4885HRH3 1359/4885SLC6A4 3211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.