Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.61 |
| ▸ | SCN1A | P35498 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.61 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6080084 | 0.85 | HRH3 (0.62) | HRH3ALDH1A1MAPK1CYP1A2CHRM2 | |
| SCHEMBL13949485 | 0.82 | EPHX2 (0.67) | HRH3ALDH1A1MAPK1CYP1A2CHRM2 | |
| SCHEMBL23291210 | 0.79 | HRH3 (0.53) | HRH3ALDH1A1MAPK1CYP1A2CHRM2 | |
| SCHEMBL18195639 | 0.79 | KDM4E (0.47) | HRH3ALDH1A1MAPK1CYP1A2CHRM2 | |
| SCHEMBL9530115 | 0.78 | ALDH1A1 (0.81) | HRH3ALDH1A1MAPK1CYP1A2CHRM2 | |
| SCHEMBL13166930 | 0.78 | HRH3 (0.74) | HRH3ALDH1A1MAPK1CYP1A2CHRM2 | |
| SCHEMBL5300447 | 0.78 | ALDH1A1 (0.64) | HRH3ALDH1A1MAPK1CYP1A2CHRM2 | |
| Pramoxine SCHEMBL26020 | 0.77 | ALDH1A1 (1.00) | HRH3ALDH1A1MAPK1CYP1A2CHRM2 | |
| SCHEMBL11929932 | 0.77 | ABHD6 (0.63) | HRH3ALDH1A1MAPK1CYP1A2CHRM2 | |
| SCHEMBL6689250 | 0.77 | ALDH1A1 (0.70) | HRH3ALDH1A1MAPK1CYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501794-A1 | THIAZOLIDINONES AND THE USE THEREOF AS POLO-LIKE KINASE INHIBITORS | Schering Aktiengesellschaft (DE) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093249-A1 | THIAZOLIDINONES AND THE USE THEREOF AS POLO-LIKE KINASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-11-13 | — | — | WO | disclosed |