Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179685 | 0.86 | AURKA (0.30) | AURKA | |
| SCHEMBL7319030 | 0.74 | IKBKB (0.43) | AURKA | |
| SCHEMBL7320863 | 0.72 | HTR2C (0.41) | AURKA | |
| SCHEMBL7324280 | 0.71 | TTK (0.38) | AURKA | |
| SCHEMBL9775094 | 0.69 | ALDH1A1 (0.47) | AURKA | |
| SCHEMBL24714362 | 0.67 | — | — | |
| SCHEMBL18232238 | 0.67 | — | — | |
| SCHEMBL9936039 | 0.67 | — | — | |
| SCHEMBL14538475 | 0.65 | — | — | |
| SCHEMBL2181538 | 0.64 | NPC1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2193131-B1 | IMIDAZO[1,2-A]PYRAZINE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS SUCH AS HEPATITIS | BIOFOCUS DPI LTD (GB) | 2013-01-30 | — | — | EP | disclosed |
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |