Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241671 | 0.89 | AURKA (0.55) | AURKAAURKBAAK1MAP4K4TTK | |
| SCHEMBL14536959 | 0.81 | TTK (0.54) | AURKAAURKBTTKFYNMAPKAPK5 | |
| SCHEMBL14537007 | 0.80 | AURKA (0.48) | AURKAAURKBMAP4K4TTKMAPKAPK5 | |
| SCHEMBL14530182 | 0.79 | AURKA (0.53) | AURKAAURKBTTKFYNMAPKAPK5 | |
| SCHEMBL14530183 | 0.79 | AURKA (0.45) | AURKAAURKBTTKFYNMAPKAPK5 | |
| SCHEMBL14529898 | 0.79 | TTK (0.44) | AURKAAURKBTTKFYNMAPKAPK5 | |
| SCHEMBL14537040 | 0.78 | AURKA (0.48) | AURKAAURKBTTKFYNMAPKAPK5 | |
| SCHEMBL8240821 | 0.77 | AURKA (0.62) | AURKAAURKBTTKSYKFYN | |
| SCHEMBL14536947 | 0.76 | AURKA (0.44) | AURKAAURKBTTKFYNMAPKAPK5 | |
| SCHEMBL13954838 | 0.74 | AURKA (0.45) | AURKAAURKBTTKMAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |