Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.44 |
| ▸ | TTK | P33981 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.38 |
| ▸ | MAPKAPK5 | Q8IW41 | 6/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240162 | 0.88 | AURKA (0.62) | AURKAAURKBTTKNPC1MAPT | |
| SCHEMBL14536959 | 0.87 | TTK (0.54) | AURKAAURKBTTKMAPKAPK5FYN | |
| SCHEMBL14536853 | 0.84 | AURKA (0.46) | AURKAAURKBTTKPTK6MAPKAPK5 | |
| SCHEMBL14537044 | 0.84 | AURKA (0.45) | AURKAAURKBTTKPTK6MAPKAPK5 | |
| SCHEMBL14529898 | 0.84 | TTK (0.44) | AURKAAURKBTTKPTK6MAPKAPK5 | |
| SCHEMBL14530182 | 0.82 | AURKA (0.53) | AURKAAURKBTTKMAPKAPK5FYN | |
| SCHEMBL14536759 | 0.82 | AURKA (0.42) | AURKAAURKBTTK | |
| SCHEMBL14537007 | 0.82 | AURKA (0.48) | AURKAAURKBTTKMAPKAPK5MKNK1 | |
| SCHEMBL14536950 | 0.81 | AURKA (0.44) | AURKAAURKBTTKPTK6 | |
| SCHEMBL14538587 | 0.81 | AURKA (0.44) | AURKAAURKBTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |