Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.46 |
| ▸ | TTK | P33981 | 2/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 9/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14536959 | 0.91 | TTK (0.54) | AURKAAURKBTTKMAPKAPK5FYN | |
| SCHEMBL14537007 | 0.87 | AURKA (0.48) | AURKAAURKBTTKMAPKAPK5 | |
| SCHEMBL8247167 | 0.86 | AURKA (0.69) | AURKAAURKBTTKMAPKAPK5FYN | |
| SCHEMBL14530020 | 0.85 | AURKA (0.62) | AURKAAURKBTTKMAPKAPK5 | |
| SCHEMBL14536833 | 0.84 | AURKA (0.48) | AURKAAURKBTTKMAPKAPK5FYN | |
| SCHEMBL14537040 | 0.82 | AURKA (0.48) | AURKAAURKBTTKMAPKAPK5FYN | |
| SCHEMBL14537008 | 0.82 | AURKA (0.46) | AURKAAURKBTTKFLT3 | |
| SCHEMBL13954838 | 0.82 | AURKA (0.45) | AURKAAURKBTTKMAPKAPK5 | |
| SCHEMBL13954584 | 0.82 | AURKA (0.53) | AURKAAURKBTTKMAPKAPK5FLT3 | |
| SCHEMBL14538587 | 0.81 | AURKA (0.44) | AURKAAURKBTTKFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058873-A2 | IMIDAZOPYRAZINES AS CYCLIN DEPENTEND KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |