Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.48 |
| ▸ | TTK | P33981 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MAPKAPK5 | Q8IW41 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14536959 | 0.90 | TTK (0.54) | AURKATTKAURKBMAPKAPK5 | |
| SCHEMBL14530182 | 0.87 | AURKA (0.53) | AURKATTKAURKBMAPKAPK5 | |
| SCHEMBL8247128 | 0.87 | AURKA (0.63) | AURKATTKAURKBMAP4K4CCNA2 | |
| SCHEMBL14537040 | 0.82 | AURKA (0.48) | AURKATTKAURKBMKNK1MAPKAPK5 | |
| SCHEMBL14538587 | 0.81 | AURKA (0.44) | AURKATTKAURKBCCNA2CDK2 | |
| SCHEMBL14529898 | 0.81 | TTK (0.44) | AURKATTKAURKBKDRMAPKAPK5 | |
| SCHEMBL14536953 | 0.80 | AURKA (0.42) | AURKATTKAURKBMAP4K4MAPKAPK5 | |
| SCHEMBL14530020 | 0.80 | AURKA (0.62) | AURKATTKAURKBCDK2CDK5 | |
| SCHEMBL14537008 | 0.80 | AURKA (0.46) | AURKATTKAURKB | |
| SCHEMBL14536833 | 0.79 | AURKA (0.48) | AURKATTKAURKBMAPKAPK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |