Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 7/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247778 | 0.89 | AURKA (0.45) | AURKBAURKATTKBRD4SIRT2 | |
| SCHEMBL14530730 | 0.73 | PTK6 (0.54) | PTK6AURKBAURKAMAPKAPK5TTK | |
| SCHEMBL9244811 | 0.73 | ALDH1A1 (0.49) | SIRT2 | |
| SCHEMBL10169406 | 0.72 | MAPKAPK5 (0.57) | PTK6AURKBAURKAMAPKAPK5LCK | |
| SCHEMBL8247133 | 0.71 | ALOX5AP (0.51) | GPR119 | |
| SCHEMBL8240624 | 0.71 | ALOX5AP (0.51) | GPR119 | |
| SCHEMBL8246047 | 0.70 | FYN (0.52) | PTK6AURKBAURKAMAPKAPK5TTK | |
| SCHEMBL30138985 | 0.70 | MAPKAPK5 (0.62) | PTK6AURKBAURKAMAPKAPK5TTK | |
| SCHEMBL5575570 | 0.70 | MAPKAPK5 (0.58) | PTK6AURKBAURKAMAPKAPK5TTK | |
| SCHEMBL9900728 | 0.69 | ALOX5AP (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058942-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |