Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14538440 | 0.92 | TRPV1 (0.39) | HDAC6TRPV1MAPTALDH1A1LMNA | |
| SCHEMBL14538442 | 0.88 | LMNA (0.44) | TRPV1MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL14667928 | 0.88 | MAPT (0.43) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL14538408 | 0.83 | MAPT (0.37) | TRPV1MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL14538489 | 0.82 | HTT (0.35) | HDAC6TRPV1MAPTALDH1A1LMNA | |
| SCHEMBL14538438 | 0.81 | MAPT (0.41) | TRPV1MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL14538414 | 0.80 | GPBAR1 (0.36) | TRPV1MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL14538436 | 0.78 | LMNA (0.42) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL14538488 | 0.78 | RAB9A (0.39) | MAPTALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL14538642 | 0.77 | MEN1 (0.42) | MAPTALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394803-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-03-12 | — | — | US | disclosed |
| US-8394803-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-03-12 | — | — | US | disclosed |
| US-20130030004-A1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2013-01-31 | — | — | US | disclosed |
| US-20130030004-A1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED | 2013-01-31 | — | — | US | disclosed |
| WO-2007056330-A1 | BENZIMIDAZOLE DERIVATIVES AS GYRASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130030004-A1 | Gyrase inhibitors and uses thereof | TOP1, TOP2A, TOP2B | HDAC6 377/4885HDAC1 240/4885TRPV1 4544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.