Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 2/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCND2 | P30279 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11931565 | 0.88 | CHEK1 (0.52) | GPR119PIK3CDCHEK1 | |
| SCHEMBL14218799 | 0.87 | CHEK1 (0.43) | GPR119PIK3CDCDK4CCND1CCND2 | |
| SCHEMBL13309406 | 0.84 | GPR119 (0.44) | GPR119PIK3CDFPR2CDK4CCND1 | |
| SCHEMBL13309217 | 0.81 | JAK2 (0.41) | FPR2GSK3BTRPV3CHEK1JAK2 | |
| SCHEMBL11931591 | 0.78 | CHEK1 (0.46) | FPR2GSK3BTRPV3CHEK1JAK2 | |
| SCHEMBL14561895 | 0.78 | ALDH1A1 (0.40) | GPR119FPR2GSK3BTRPV3CHEK1 | |
| SCHEMBL14541613 | 0.78 | TRPV3 (0.43) | PIK3CDFPR2TRPV3CHEK1JAK2 | |
| SCHEMBL14541702 | 0.78 | GSK3B (0.58) | GSK3BCHEK1 | |
| SCHEMBL11931582 | 0.77 | CHEK1 (0.56) | CHEK1USP30 | |
| SCHEMBL14942244 | 0.77 | CHEK1 (0.53) | FPR2TRPV3CHEK1JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934224-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS FOR THE TREATMENT OF CANCER | SCHERING CORP (US) | 2010-06-09 | — | — | EP | disclosed |
| US-7205308-B2 | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-04-17 | — | — | US | disclosed |