Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 19/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.52 |
| ▸ | CDK2 | P24941 | 10/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 10/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784500 | 0.83 | CHEK1 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14542883 | 0.81 | CHEK1 (0.78) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14542920 | 0.79 | CHEK1 (0.69) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931630 | 0.79 | PIK3CA (0.37) | — | |
| SCHEMBL11930965 | 0.77 | CHEK1 (0.66) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14542703 | 0.77 | CHEK1 (0.66) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14543105 | 0.76 | CHEK1 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14543108 | 0.76 | CHEK1 (0.77) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14542953 | 0.76 | CHEK1 (0.73) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL17826802 | 0.76 | CHEK1 (0.57) | CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942900-B1 | USE OF PYRAZOLO [1,5-A] PYRIMIDINE DERIVATIVES FOR INHIBITING KINASES METHODS FOR INHIBITING PROTEIN KINASES | MERCK SHARP & DOHME (US) | 2015-06-03 | — | — | EP | disclosed |