⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL4049605 | 0.97 | CA1 (0.36) | — | |
| SCHEMBL13859438 | 0.76 | CA1 (0.44) | — | |
| SCHEMBL13499 | 0.71 | — | — | |
| SCHEMBL8015144 | 0.69 | CES2 (0.36) | — | |
| SCHEMBL4008449 | 0.69 | — | — | |
| SCHEMBL954349 | 0.69 | — | — | |
| SCHEMBL6560890 | 0.67 | — | — | |
| Fluoride SCHEMBL21816906 | 0.67 | CA1 (0.57) | — | |
| Bromide SCHEMBL6770232 | 0.67 | — | — | |
| Iodide SCHEMBL2216576 | 0.66 | ACHE (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012155932-A1 | IMPROVED PROCESS FOR THE PREPARATION OF EZETIMIBE | PHARMATHEN S.A. (GR) | 2012-11-22 | — | — | WO | claimed |
| EP-1819684-B1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | INTERVET INT BV (NL) | 2013-08-07 | — | — | EP | disclosed |
| US-20130190487-A1 | PROCESS FOR THE PREPARATION OF EZETIMIBE AND DERIVATIVES THEREOF | KRKA (SL) | 2013-07-25 | — | — | US | disclosed |
| US-20130072468-A1 | SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS | GILBERT ERIC J (US) | 2013-03-21 | — | — | US | disclosed |
| US-8236805-B2 | Substituted piperazines as CB1 antagonists | INTERVET INC. (US) | 2012-08-07 | — | — | US | disclosed |
| US-RE42461-E1 | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents | SCHERING CORPORATION (US) | 2011-06-14 | — | — | US | disclosed |
| US-7910783-B2 | Preparation of substituted bridged indenyl and related ligands | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2011-03-22 | — | — | US | disclosed |
| US-7737154-B2 | CRF receptor antagonists and methods relating thereto | SMITHKLINE BEECHAM (CORK) LIMITED (IE) | 2010-06-15 | — | — | US | disclosed |
| EP-2189442-A1 | Process and intermediates for the preparation of aliskiren | Krka Tovarna Zdravil, D.D., Novo Mesto (SI) | 2010-05-26 | — | — | EP | disclosed |
| US-7700597-B2 | Substituted piperazines as CB1 antagonists | SCHERING CORPORATION (US) | 2010-04-20 | — | — | US | disclosed |
| US-RE37721-E1 | Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents | SCHERING CORPORATION | 2002-05-28 | — | — | US | disclosed |
| EP-0692485-B1 | Cyclohexane carbaldehyde compounds and processes for preparing silacyclohexane-based liquid crystal compounds from the carbaldehyde compound | SHINETSU CHEMICAL CO (JP) | 2000-01-05 | — | — | EP | disclosed |
| EP-0720599-B1 | HYDROXY-SUBSTITUTED AZETIDINONE COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORP (US) | 1999-05-19 | — | — | EP | disclosed |
| US-5846966-A | Ezetimibe in combination with statins | SCHERING CORPORATION (US) | 1998-12-08 | — | — | US | disclosed |
| US-5767115-A | ADMINISTERING TO PREVENT ATHERSCLEROSIS OR REDUCING PLASMA CHOLESTEROL LEVELS TO THE MAMMALS; INCLUDES EZETIMIBE | SCHERING-PLOUGH CORPORATION (US) | 1998-06-16 | — | — | US | disclosed |
| US-5631365-A | TREATING LACTONE WITH BASE; REACTING WITH AROMATIC IMINE; LACTAMIZATION | SCHERING CORPORATION (US) | 1997-05-20 | — | — | US | disclosed |
| EP-0720599-A1 | HYDROXY-SUBSTITUTED AZETIDINONE COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORPORATION (US) | 1996-07-10 | — | — | EP | disclosed |
| US-5519156-A | Cyclohexane carbaldehyde compounds and processes for preparing silacyclohexane-based liquid crystal compounds from the carbaldehyde | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1996-05-21 | — | — | US | disclosed |
| EP-0692485-A1 | Cyclohexane carbaldehyde compounds and processes for preparing silacyclohexane-based liquid crystal compounds from the carbaldehyde compound | Shin-Etsu Chemical Co., Ltd. (JP) | 1996-01-17 | — | — | EP | disclosed |
| WO-1995008532-A1 | HYDROXY-SUBSTITUTED AZETIDINONE COMPOUNDS USEFUL AS HYPOCHOLESTEROLEMIC AGENTS | SCHERING CORPORATION (US) | 1995-03-30 | — | — | WO | disclosed |