Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 6/20 | 0.45 |
| ▸ | CDK1 | P06493 | 6/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.45 |
| ▸ | GSK3A | P49840 | 5/20 | 0.45 |
| ▸ | GSK3B | P49841 | 5/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4940959 | 0.87 | CCNB2 (0.46) | CCNB2CDK1CCNB1CCNB3GSK3A | |
| SCHEMBL1839873 | 0.85 | PARP1 (0.41) | GSK3BCDK5CDK5R1KMT2ADYRK1A | |
| SCHEMBL4937417 | 0.84 | CCNB2 (0.43) | CCNB2CDK1CCNB1CCNB3GSK3A | |
| SCHEMBL4935159 | 0.84 | MEN1 (0.41) | CCNB2CDK1CCNB1CCNB3GSK3A | |
| SCHEMBL4941364 | 0.83 | MAPK14 (0.52) | CCNB2CDK1CCNB1CCNB3GSK3A | |
| SCHEMBL1839112 | 0.81 | CCNB2 (0.40) | CCNB2CDK1CCNB1CCNB3GSK3A | |
| SCHEMBL1839021 | 0.80 | MKNK2 (0.53) | CDK1GSK3AGSK3BCDK5CDK2 | |
| SCHEMBL4934478 | 0.79 | ALDH1A1 (0.50) | GSK3AGSK3BKMT2AMAPTCHEK2 | |
| SCHEMBL4939133 | 0.78 | PTGS2 (0.49) | CCNB2CDK1CCNB1CCNB3GSK3A | |
| SCHEMBL4930977 | 0.78 | TBK1 (0.57) | GSK3AGSK3BKMT2AMAPTMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007040438-A2 | NOVEL IMIDAZO [4,5 -B] PYRIDINE DERIVATIVES AS INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 FOR USE IN THE TREATMENT OF DEMENTIA AND NEURODEGENERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |