Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.53 |
| ▸ | GSK3B | P49841 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288743 | 0.90 | CDK2 (0.67) | CDK2GSK3B | |
| SCHEMBL14545970 | 0.87 | GSK3B (0.45) | CDK2GSK3BCYP2C19 | |
| SCHEMBL13288868 | 0.87 | CDK2 (0.52) | CDK2GSK3BCYP2C9CYP2C19 | |
| SCHEMBL13288754 | 0.87 | CDK2 (0.45) | CDK2GSK3BSMN1; SMN2KMT2ALMNA | |
| SCHEMBL14545832 | 0.86 | CDK2 (0.48) | CDK2GSK3BSMN1; SMN2LMNANPC1 | |
| SCHEMBL14613373 | 0.86 | EPHX2 (0.44) | CDK2GSK3BSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL13288854 | 0.86 | GSK3B (0.48) | CDK2GSK3BSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL13288899 | 0.84 | GSK3B (0.43) | CDK2GSK3BSMN1; SMN2KMT2ANPC1 | |
| SCHEMBL13120200 | 0.84 | CDK2 (0.65) | CDK2GSK3BPOLB | |
| SCHEMBL13288895 | 0.84 | GSK3B (0.43) | CDK2GSK3BSMN1; SMN2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |