Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14561755 | 0.91 | GSK3B (0.56) | GSK3BCDK2ALDH1A1MEN1KMT2A | |
| SCHEMBL13288754 | 0.89 | CDK2 (0.45) | GSK3BCDK2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14545970 | 0.87 | GSK3B (0.45) | GSK3BCDK2CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL13288943 | 0.87 | BRD4 (0.44) | GSK3BCDK2ALDH1A1MEN1KMT2A | |
| SCHEMBL14545832 | 0.87 | CDK2 (0.48) | GSK3BCDK2ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL13120086 | 0.86 | GSK3B (0.55) | GSK3BCDK2ALDH1A1MEN1KMT2A | |
| SCHEMBL13120159 | 0.86 | GSK3B (0.55) | GSK3BCDK2ALDH1A1MEN1KMT2A | |
| SCHEMBL13289235 | 0.85 | CDK2 (0.45) | GSK3BCDK2ALDH1A1KMT2AHPGD | |
| SCHEMBL13288899 | 0.85 | GSK3B (0.43) | GSK3BCDK2ALDH1A1MEN1KMT2A | |
| SCHEMBL14545261 | 0.84 | CDK2 (0.53) | GSK3BCDK2MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |