Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14545834 | 0.90 | GSK3B (0.44) | CDK2ALDH1A1GSK3BMAPK1L3MBTL1 | |
| SCHEMBL13288897 | 0.90 | CDK2 (0.43) | CDK2ALDH1A1LMNAGSK3BMAPT | |
| SCHEMBL13120245 | 0.89 | CDK2 (0.62) | CDK2ALDH1A1LMNAGSK3BMAPT | |
| SCHEMBL13288854 | 0.88 | GSK3B (0.48) | CDK2GSK3BSMN1; SMN2 | |
| SCHEMBL13288754 | 0.87 | CDK2 (0.45) | CDK2LMNAGSK3BMAPTNPC1 | |
| SCHEMBL14545970 | 0.87 | GSK3B (0.45) | CDK2GSK3B | |
| SCHEMBL13288895 | 0.87 | GSK3B (0.43) | CDK2ALDH1A1LMNAGSK3BMAPT | |
| SCHEMBL14545261 | 0.86 | CDK2 (0.53) | CDK2LMNAGSK3BMAPTNPC1 | |
| SCHEMBL13289308 | 0.86 | CDK2 (0.53) | CDK2ALDH1A1GSK3BMAPTMAPK1 | |
| SCHEMBL13288867 | 0.86 | CDK2 (0.47) | CDK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |