Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14413493 | 0.84 | CHEK1 (0.32) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14545929 | 0.83 | CDK2 (0.43) | TLR7CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14050984 | 0.80 | MALT1 (0.38) | EPHA2 | |
| SCHEMBL14545930 | 0.78 | CHEK1 (0.34) | CHEK1CCNA2CDK2CCNA1GSK3B | |
| SCHEMBL14413501 | 0.71 | CHEK1 (0.41) | CHEK1CCNA2CDK2CCNA1GSK3B | |
| SCHEMBL10460653 | 0.71 | GSK3B (0.49) | TLR9CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14413523 | 0.70 | CHEK1 (0.39) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14413470 | 0.69 | GSK3B (0.33) | CHEK1CCNA2CDK2CCNA1GSK3B | |
| SCHEMBL14413496 | 0.68 | CHEK1 (0.34) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14542953 | 0.67 | CHEK1 (0.73) | CHEK1CCNA2CDK2CCNA1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |