Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14413496 | 0.84 | CHEK1 (0.34) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14545929 | 0.81 | CDK2 (0.43) | CHEK1CCNA2CDK2CCNA1GSK3B | |
| SCHEMBL14545936 | 0.78 | LRRK2 (0.36) | CHEK1CCNA2CDK2CCNA1GSK3B | |
| SCHEMBL14545924 | 0.70 | CDK2 (0.33) | CHEK1CCNA2CDK2CCNA1GSK3B | |
| SCHEMBL14413524 | 0.70 | CHEK1 (0.41) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14413501 | 0.69 | CHEK1 (0.41) | CHEK1CCNA2CDK2CCNA1GSK3B | |
| SCHEMBL14413483 | 0.69 | CHEK1 (0.33) | CHEK1CCNA2CDK2CCNA1GSK3B | |
| SCHEMBL10460653 | 0.68 | GSK3B (0.49) | CHEK1CCNA2CDK2CCNA1GSK3B | |
| SCHEMBL14413493 | 0.68 | CHEK1 (0.32) | CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL14542953 | 0.67 | CHEK1 (0.73) | CHEK1CCNA2CDK2CCNA1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |