Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.33 |
| ▸ | GSK3B | P49841 | 5/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14547249 | 1.00 | CDK2 (0.33) | CDK2GSK3BCSNK2BCDK7CCNE1 | |
| SCHEMBL11930886 | 0.80 | GSK3B (0.41) | CDK2GSK3BCSNK2BCDK7CCNE1 | |
| SCHEMBL14547315 | 0.79 | GSK3B (0.48) | CDK2GSK3BCHEK1CCNA2CCNA1 | |
| SCHEMBL15579759 | 0.77 | GSK3B (0.34) | CDK2GSK3BCSNK2BCDK7CCNE1 | |
| SCHEMBL15381890 | 0.77 | GSK3B (0.34) | CDK2GSK3BCSNK2BCDK7CCNE1 | |
| SCHEMBL11930880 | 0.77 | CDK2 (0.47) | CDK2GSK3BMAPKAPK2CHEK1CCNA2 | |
| SCHEMBL12954276 | 0.77 | TTK (0.46) | CDK2GSK3BCSNK2BCDK7CCNE1 | |
| SCHEMBL11930887 | 0.76 | GSK3B (0.38) | CDK2GSK3BCSNK2BCDK7CCNE1 | |
| SCHEMBL12954035 | 0.75 | GSK3B (0.41) | CDK2GSK3BCDK7CCNE1CCNH | |
| SCHEMBL14276368 | 0.75 | OPRK1 (0.36) | CDK2GSK3BCDK7CCNE1CCNH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044401-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |