SCHEMBL1454792

SCHEMBL1454792

CN(C)c1ccc(C=C2C(=O)c3ccccc3C2=O)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MIF P14174 1/20 0.70
MAPT P10636 9/20 0.63
ALDH1A1 P00352 7/20 0.63
APP P05067 6/20 0.63
SNCA P37840 6/20 0.63
MEN1 O00255 5/20 0.63
KMT2A Q03164 5/20 0.63
MAPK1 P28482 3/20 0.63
TDP1 Q9NUW8 3/20 0.63
PDGFRB P09619 2/20 0.63
LMNA P02545 2/20 0.63
HPGD P15428 2/20 0.63
PKM P14618 2/20 0.63
SMN1; SMN2 Q16637 2/20 0.63
NPC1 O15118 1/20 0.63
GMNN O75496 1/20 0.63
MTOR P42345 1/20 0.63
RAB9A P51151 1/20 0.63
BLM P54132 1/20 0.63
PMP22 Q01453 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29609334 1.00 MIF (0.70) MIFMAPTALDH1A1APPSNCA
SCHEMBL34474369 0.95 MIF (0.65) MIFMAPTALDH1A1APPSNCA
SCHEMBL25850280 0.87 MIF (0.59) MIFMAPTALDH1A1APPSNCA
SCHEMBL22625286 0.84 LCK (0.66) MAPTALDH1A1APPMEN1KMT2A
SCHEMBL136295 0.83 MAPT (0.59) MIFMAPTALDH1A1APPSNCA
SCHEMBL2716738 0.82 LCK (0.51) MIFMAPTALDH1A1APPSNCA
SCHEMBL19136641 0.82 MIF (0.54) MIFMAPTALDH1A1APPSNCA
SCHEMBL31022832 0.82 MAPT (0.57) MIFMAPTALDH1A1APPSNCA
SCHEMBL19136640 0.82 MIF (0.54) MIFMAPTALDH1A1APPSNCA
SCHEMBL10134134 0.81 KMT2A (0.53) MIFMAPTALDH1A1APPSNCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0319296-A2 Photopolymerisable composition Horsell Plc (GB) 1989-06-07 EP claimed
EP-4208551-A1 RNA-APTAMER-SENSORS SenseUp GmbH (DE) 2023-07-12 EP disclosed
WO-2020223439-A1 AURONES AND METHODS OF USING AURONES TO TREAT TUBERCULOSIS Middle Tennessee State University (US) 2020-11-05 WO disclosed
US-20110190492-A1 DIAGNOSTIC PROBE FOR CONFORMATION DISEASE TOHOKU UNIVERSITY (JP) 2011-08-04 US disclosed
US-20110190492-A1 DIAGNOSTIC PROBE FOR CONFORMATION DISEASE TOHOKU UNIVERSITY (JP) 2011-08-04 US disclosed
US-7910579-B2 Benzoxazole derivatives TOHOKU UNIVERSITY (JP) 2011-03-22 US disclosed
US-7910579-B2 Benzoxazole derivatives TOHOKU UNIVERSITY (JP) 2011-03-22 US disclosed
US-7910579-B2 Benzoxazole derivatives TOHOKU UNIVERSITY (JP) 2011-03-22 US disclosed
US-20100021385-A1 BENZOXAZOLE DERIVATIVES TOHOKU UNIVERSITY (JP) 2010-01-28 US disclosed
US-20100021385-A1 BENZOXAZOLE DERIVATIVES TOHOKU UNIVERSITY (JP) 2010-01-28 US disclosed
US-20100021385-A1 BENZOXAZOLE DERIVATIVES TOHOKU UNIVERSITY (JP) 2010-01-28 US disclosed
EP-2103611-A1 BENZOXAZOLE DERIVATIVES Tohoku University (JP) 2009-09-23 EP disclosed
US-20090185975-A1 DIAGNOSTIC PROBE FOR CONFORMATION DISEASE TOHOKU UNIVERSITY (JP) 2009-07-23 US disclosed
US-20090185975-A1 DIAGNOSTIC PROBE FOR CONFORMATION DISEASE TOHOKU UNIVERSITY (JP) 2009-07-23 US disclosed
US-20090185975-A1 DIAGNOSTIC PROBE FOR CONFORMATION DISEASE TOHOKU UNIVERSITY (JP) 2009-07-23 US disclosed
EP-1967517-A1 PROBE FOR DIAGNOSIS OF CONFORMATIONAL DISEASE TOHOKU UNIVERSITY (JP) 2008-09-10 EP disclosed
EP-0319296-A2 Photopolymerisable composition Horsell Plc (GB) 1989-06-07 EP disclosed
US-3973959-A Electrophotographic recording material and process for its manufacture HOECHST AKTIENGESELLSCHAFT (DT) 1976-08-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090185975-A1 DIAGNOSTIC PROBE FOR CONFORMATION DISEASE TARDBP, LMNA, PMP22 MIF 3831/4885MAPT 213/4885ALDH1A1 2945/4885
US-20100021385-A1 BENZOXAZOLE DERIVATIVES CBX7, KIT, BMX MIF 4389/4885MAPT 1385/4885ALDH1A1 1195/4885
US-20110190492-A1 DIAGNOSTIC PROBE FOR CONFORMATION DISEASE TARDBP, LMNA, PMP22 MIF 3831/4885MAPT 213/4885ALDH1A1 2945/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.