Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 10/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | NNMT | P40261 | 1/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20321443 | 0.86 | EEF2K (0.44) | CASP1POLBPARP1LMNAJAK2 | |
| SCHEMBL4990777 | 0.83 | KEAP1 (0.56) | POLBLMNAKEAP1NFE2L2GRM1 | |
| SCHEMBL5796439 | 0.77 | KEAP1 (0.35) | LMNAKEAP1NFE2L2GRM1 | |
| SCHEMBL9703868 | 0.77 | POLB (0.52) | CASP1POLBLMNAKEAP1NFE2L2 | |
| SCHEMBL30170611 | 0.77 | POLB (0.52) | CASP1POLBLMNAKEAP1NFE2L2 | |
| SCHEMBL566114 | 0.76 | CASP1 (0.47) | CASP1POLBLMNAKEAP1NFE2L2 | |
| SCHEMBL29406095 | 0.76 | CASP1 (0.47) | CASP1POLBLMNAKEAP1NFE2L2 | |
| SCHEMBL30028472 | 0.74 | PARP1 (0.57) | CASP1POLBPARP1LMNANNMT | |
| SCHEMBL7846286 | 0.73 | GABRP (0.42) | POLBPARP1 | |
| SCHEMBL166218 | 0.73 | KEAP1 (0.69) | CASP1POLBLMNAJAK2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013004785-A1 | HETEROARYL-SUBSTITUTED PYRAZOLOPYRIDINES AND USE THEREOF AS SOLUBLE GUANYLATE CYCLASE STIMULATORS | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-01-10 | — | — | WO | disclosed |