Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.71 |
| ▸ | MAPT | P10636 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.71 |
| ▸ | HPGD | P15428 | 3/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.51 |
| ▸ | TNKS | O95271 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | EDNRB | P24530 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Taiwanin E SCHEMBL15363973 | 0.92 | MEN1 (0.82) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL23065639 | 0.89 | MEN1 (0.77) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL14554774 | 0.88 | KDM4E (0.72) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10018117 | 0.86 | MEN1 (0.78) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| Diphyllin SCHEMBL1061765 | 0.83 | ALDH1A1 (1.00) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL23686043 | 0.83 | MEN1 (0.70) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| Diphyllin SCHEMBL30887017 | 0.83 | ALDH1A1 (1.00) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL2958006 | 0.83 | MEN1 (0.63) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL23065672 | 0.81 | ALDH1A1 (0.90) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL23686045 | 0.81 | MEN1 (0.76) | KDM4EMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210230149-A1 | ARYLNAPHTHALENE COMPOUNDS AS VACUOLAR-ATPASE INHIBITORS AND THE USE THEREOF | PURDUE RESEARCH FOUNDATION (US) | 2021-07-29 | — | — | US | disclosed |
| US-8957230-B2 | Synthesis of cleistanthin A and derivatives thereof | GODAVARI BIOREFINERIES LIMITED (IN) | 2015-02-17 | — | — | US | disclosed |
| US-20130012727-A1 | SYNTHESIS OF CLEISTANTHIN A AND DERIVATIVES THEREOF | GODAVARI BIOREFINERIES LIMITED | 2013-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012727-A1 | SYNTHESIS OF CLEISTANTHIN A AND DERIVATIVES THEREOF | STT3A, DDOST, MAGT1 | KDM4E 1188/4885MAPT 3436/4885ALDH1A1 1981/4885 |
| US-20210230149-A1 | ARYLNAPHTHALENE COMPOUNDS AS VACUOLAR-ATPASE INHIBITORS AND THE USE THEREOF | VCP, ATP6V1H, NSF | KDM4E 3372/4885MAPT 1923/4885ALDH1A1 1609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.