Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 2/20 | 0.43 |
| ▸ | IKBKB | O14920 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5343724 | 0.99 | WNT1 (0.48) | WNT1DYRK1AHTR3APPARGRAB9A | |
| SCHEMBL31500280 | 0.84 | HTR3A (0.48) | HTR3ARAB9ACYP1A2L3MBTL1KDM4E | |
| SCHEMBL5338609 | 0.82 | KMO (0.55) | PPARGRAB9ACYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL5741076 | 0.77 | HTR3A (0.51) | HTR3ARAB9AL3MBTL1KDM4EPKM | |
| SCHEMBL13686281 | 0.76 | KMT2A (0.50) | WNT1DYRK1AHTR3APPARGRAB9A | |
| SCHEMBL21262025 | 0.75 | HTR3A (0.51) | HTR3ACYP1A2ALOX15CYP2C19KDM4E | |
| SCHEMBL989945 | 0.75 | HTR3A (0.43) | WNT1DYRK1AHTR3APPARGRAB9A | |
| SCHEMBL30380253 | 0.73 | POLB (0.39) | KDM4EPKMMEN1ALDH1A1KMT2A | |
| SCHEMBL30381113 | 0.73 | KMT2A (0.32) | WNT1DYRK1ASMOL3MBTL1KDM4E | |
| SCHEMBL5340834 | 0.73 | TDP1 (0.56) | RAB9AALOX15L3MBTL1KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186743-B2 | Substituted pyrazolyl compounds for the treatment of inflammation | PHARMACIA CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186743-B2 | Substituted pyrazolyl compounds for the treatment of inflammation | PHARMACIA CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |