Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.36 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11931591 | 0.92 | CHEK1 (0.46) | ALDH1A1KDM4EMEN1KMT2ACRHBP | |
| SCHEMBL11931622 | 0.82 | CHEK1 (0.46) | ALDH1A1KDM4EMEN1KMT2ACRHBP | |
| SCHEMBL14561898 | 0.81 | ALDH1A1 (0.37) | ALDH1A1KDM4EMEN1KMT2ACRHBP | |
| SCHEMBL14541613 | 0.80 | TRPV3 (0.43) | ALDH1A1KDM4EMEN1KMT2ACRHBP | |
| SCHEMBL11931578 | 0.80 | CHEK1 (0.47) | ALDH1A1KDM4ETRPV3HPGDCHEK1 | |
| SCHEMBL14942244 | 0.79 | CHEK1 (0.53) | ALDH1A1KDM4EMEN1KMT2ACRHBP | |
| SCHEMBL11931323 | 0.79 | TRPV3 (0.43) | ALDH1A1KDM4EMEN1KMT2ACRHBP | |
| SCHEMBL13309217 | 0.79 | JAK2 (0.41) | TRPV3CHEK1CDK2GSK3BFPR2 | |
| SCHEMBL14218635 | 0.79 | CHEK1 (0.51) | TRPV3CHEK1CCNA2CDK2CCNA1 | |
| SCHEMBL11931577 | 0.79 | CHEK1 (0.65) | CHEK1CCNA2CDK2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196092-B2 | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-03-27 | — | — | US | disclosed |