Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13309134 | 0.85 | TRPV3 (0.39) | JAK2JAK3PTK2TRPV3FPR2 | |
| SCHEMBL14519195 | 0.84 | TRPV3 (0.37) | JAK2JAK3PTK2TRPV3FPR2 | |
| SCHEMBL13309478 | 0.81 | GPR119 (0.44) | JAK2JAK3PTK2TRPV3FPR2 | |
| SCHEMBL11931591 | 0.79 | CHEK1 (0.46) | JAK2JAK3TRPV3FPR2GSK3B | |
| SCHEMBL14561895 | 0.79 | ALDH1A1 (0.40) | JAK2TRPV3FPR2GSK3BCDK2 | |
| SCHEMBL14541613 | 0.79 | TRPV3 (0.43) | JAK2TRPV3FPR2HPGDSCDK2 | |
| SCHEMBL14942244 | 0.78 | CHEK1 (0.53) | JAK2TRPV3FPR2HPGDSCDK2 | |
| SCHEMBL11931323 | 0.78 | TRPV3 (0.43) | JAK2TRPV3FPR2HPGDSCDK2 | |
| SCHEMBL14541358 | 0.78 | CHEK1 (0.57) | GSK3BCDK2CHEK1 | |
| SCHEMBL11931324 | 0.77 | TRPV3 (0.42) | JAK2TRPV3FPR2HPGDSCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934224-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS FOR THE TREATMENT OF CANCER | SCHERING CORP (US) | 2010-06-09 | — | — | EP | disclosed |
| US-7205308-B2 | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-04-17 | — | — | US | disclosed |