Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.65 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14562013 | 0.89 | PTGS2 (0.70) | PTGS2EPHX2PTGS1ALOX5CA1 | |
| SCHEMBL3864236 | 0.83 | PTGS2 (0.90) | PTGS2EPHX2PTGS1ALOX5CA1 | |
| SCHEMBL3866543 | 0.81 | PTGS2 (0.70) | PTGS2EPHX2PTGS1ALOX5CA1 | |
| SCHEMBL3867352 | 0.81 | PTGS2 (0.64) | PTGS2EPHX2PTGS1ALOX5CA9 | |
| SCHEMBL14562005 | 0.81 | CA9 (0.72) | PTGS2PTGS1ALOX5CA1CA2 | |
| SCHEMBL9941289 | 0.79 | PTGS2 (1.00) | PTGS2EPHX2PTGS1ALOX5CA1 | |
| SCHEMBL3866134 | 0.78 | PTGS2 (0.64) | PTGS2EPHX2PTGS1ALOX5CA1 | |
| SCHEMBL9199654 | 0.77 | RPA1 (0.72) | PTGS2ALOX5 | |
| SCHEMBL28782961 | 0.77 | TSHR (0.48) | — | |
| SCHEMBL9941646 | 0.77 | ALOX5 (0.69) | PTGS2EPHX2PTGS1ALOX5CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070060629-A1 | Large conductance calcium-activated k channel opener | TANABE SEIYAKU CO., LTD. (JP) | 2007-03-15 | — | — | US | disclosed |
| US-20070060629-A1 | Large conductance calcium-activated k channel opener | TANABE SEIYAKU CO., LTD. (JP) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060629-A1 | Large conductance calcium-activated k channel opener | KCNN3, KCNN1, KCNN2 | PTGS2 594/4885EPHX2 4219/4885PTGS1 558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.