Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 7/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CD74 | P04233 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2556083 | 0.89 | MAPK1 (0.42) | MAPK1MEN1KMT2AGPR119MAPT | |
| SCHEMBL14563261 | 0.88 | MEN1 (0.36) | TNIKMIFMEN1KMT2APOLB | |
| SCHEMBL2546963 | 0.84 | BRD4 (0.43) | MAPK1MEN1KMT2APOLBKDM4E | |
| SCHEMBL2545825 | 0.82 | USP2 (0.41) | TNIKMAPK1MIFMEN1KMT2A | |
| SCHEMBL3631784 | 0.80 | GPR119 (0.38) | MAPK1GPR119PIK3CD | |
| SCHEMBL2545745 | 0.78 | WNT3A (0.41) | GPR119ALDH1A1LMNA | |
| SCHEMBL2543313 | 0.78 | MIF (0.47) | TNIKMIFMEN1KMT2APOLB | |
| SCHEMBL13039415 | 0.77 | KMT2A (0.49) | MAPK1MIFMEN1KMT2APOLB | |
| SCHEMBL2542519 | 0.76 | POLB (0.43) | TNIKMIFMEN1KMT2APOLB | |
| SCHEMBL2545811 | 0.75 | POLB (0.41) | TNIKMIFMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |