Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.33 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 2/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2545745 | 0.90 | WNT3A (0.41) | PIK3CAALDH1A1LMNATBK1WNT3A | |
| SCHEMBL14563194 | 0.88 | TNIK (0.33) | MEN1KMT2AKDM4EPIK3CDALDH1A1 | |
| SCHEMBL2543647 | 0.82 | HTR6 (0.42) | MEN1KMT2ACYP3A4KDM4ECYP1A2 | |
| SCHEMBL3631469 | 0.81 | PIK3CA (0.42) | MEN1KMT2ACYP3A4KDM4ECYP1A2 | |
| SCHEMBL2556083 | 0.78 | MAPK1 (0.42) | MEN1KMT2ACYP2C19PIK3CATBK1 | |
| SCHEMBL3636656 | 0.75 | MET (0.52) | — | |
| SCHEMBL2546963 | 0.71 | BRD4 (0.43) | MEN1KMT2ACYP3A4KDM4ECYP1A2 | |
| SCHEMBL2543313 | 0.71 | MIF (0.47) | MEN1KMT2APIK3CDTNIKMIF | |
| SCHEMBL2542519 | 0.69 | POLB (0.43) | MEN1KMT2AKDM4EPIK3CDALDH1A1 | |
| SCHEMBL2545825 | 0.69 | USP2 (0.41) | MEN1KMT2ACYP3A4CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150551-B1 | 2-OXO-3-BENZYL-BENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2013-01-16 | — | — | EP | disclosed |