Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 12/20 | 1.00 |
| ▸ | DRD2 | P14416 | 4/20 | 0.66 |
| ▸ | HTR2A | P28223 | 3/20 | 0.66 |
| ▸ | HTR6 | P50406 | 3/20 | 0.66 |
| ▸ | DRD1 | P21728 | 3/20 | 0.66 |
| ▸ | HTR2C | P28335 | 2/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1456479 | 0.89 | HTR7 (0.88) | HTR7DRD2HTR2AHTR6DRD1 | |
| SCHEMBL1455629 | 0.88 | HTR7 (1.00) | HTR7DRD2HTR2AHTR6DRD1 | |
| SCHEMBL4612142 | 0.83 | HTR7 (1.00) | HTR7DRD2HTR2AHTR6DRD1 | |
| SCHEMBL4612355 | 0.80 | HTR7 (1.00) | HTR7DRD2HTR2AHTR6DRD1 | |
| SCHEMBL4612207 | 0.80 | HTR7 (1.00) | HTR7DRD2HTR2AHTR6DRD1 | |
| Hydrochloric Acid SCHEMBL4612036 | 0.79 | HTR7 (0.83) | HTR7DRD2HTR2AHTR6DRD1 | |
| SCHEMBL4612265 | 0.78 | HTR7 (1.00) | HTR7DRD2HTR2AHTR6DRD1 | |
| SCHEMBL4613692 | 0.77 | HTR7 (0.80) | HTR7DRD2HTR2AHTR6DRD1 | |
| SCHEMBL9373707 | 0.77 | HTR7 (0.69) | HTR7DRD2HTR2AHTR6DRD1 | |
| SCHEMBL4519313 | 0.76 | KCNH2 (0.85) | HTR7DRD2HTR2AHTR6DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7910591-B2 | e.g. 3-[4-(4-Pyridine-2-yl-piperazine-1-yl)-butyl]-1,3-dihydro-2H-indol-2-one; serotonin 5-HT7 and alpha 1 receptors modulator; antxiolytic agent, antidepressant; neurodegenerative diseases; schizophrenia, Alzheimer's disease, stroke, dementias; side effect reduction | EGIS GYOGYSZERGYAR NYRT. (HU) | 2011-03-22 | — | — | US | claimed |
| EP-1751105-B1 | PIPERAZINE DERIVATIVES OF ALKYL OXINDOLES | EGIS GYOGYSZERGYAR NYRT (HU) | 2008-10-29 | — | — | EP | claimed |
| US-20080161323-A1 | Piperazine Derivatives of Alkyl Oxindoles | EGIS GYOGYSZERGYAR RT. (HU) | 2008-07-03 | — | — | US | claimed |
| EP-1751105-A1 | PIPERAZINE DERIVATIVES OF ALKYL OXINDOLES | EGIS Gyógyszergyár Nyrt (HU) | 2007-02-14 | — | — | EP | claimed |
| WO-2005108364-A1 | PIPERAZINE DERIVATIVES OF ALKYL OXINDOLES | EGIS GYÓGYSZERGYÁR NYRT. (HU) | 2005-11-17 | — | — | WO | claimed |
| US-7910591-B2 | e.g. 3-[4-(4-Pyridine-2-yl-piperazine-1-yl)-butyl]-1,3-dihydro-2H-indol-2-one; serotonin 5-HT7 and alpha 1 receptors modulator; antxiolytic agent, antidepressant; neurodegenerative diseases; schizophrenia, Alzheimer's disease, stroke, dementias; side effect reduction | EGIS GYOGYSZERGYAR NYRT. (HU) | 2011-03-22 | — | — | US | disclosed |
| EP-1751105-B1 | PIPERAZINE DERIVATIVES OF ALKYL OXINDOLES | EGIS GYOGYSZERGYAR NYRT (HU) | 2008-10-29 | — | — | EP | disclosed |
| US-20080161323-A1 | Piperazine Derivatives of Alkyl Oxindoles | EGIS GYOGYSZERGYAR RT. (HU) | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161323-A1 | Piperazine Derivatives of Alkyl Oxindoles | TPH2, CNR2, HTR5A | HTR7 25/4885DRD2 28/4885HTR2A 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.