Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5119052 | 0.90 | CHRM4 (0.42) | P2RX7CHRM4TRPA1ITGB3ITGB1 | |
| SCHEMBL1456887 | 0.88 | TRPA1 (0.41) | TRPA1TRPV1MALT1 | |
| SCHEMBL5052731 | 0.84 | TRPA1 (0.46) | TRPA1TRPV1MALT1 | |
| SCHEMBL5050042 | 0.82 | P2RX7 (0.41) | P2RX7CHRM4TRPA1TRPV1CNR1 | |
| SCHEMBL1456908 | 0.82 | KIT (0.43) | — | |
| SCHEMBL1457262 | 0.81 | TRPA1 (0.42) | TRPA1TRPV1 | |
| SCHEMBL5115830 | 0.81 | KDM4E (0.46) | CHRM4TRPA1MALT1 | |
| SCHEMBL1456956 | 0.80 | RBP4 (0.47) | TRPA1TRPV1MALT1 | |
| SCHEMBL1457191 | 0.80 | TRPA1 (0.50) | TRPA1TRPV1 | |
| SCHEMBL1457200 | 0.80 | TRPA1 (0.46) | TRPA1TRPV1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292625-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-12-25 | — | — | EP | claimed |
| EP-2292625-A1 | Substituted spiro compounds and their use for producing pain-relief medicaments | Grünenthal GmbH (DE) | 2011-03-09 | — | — | EP | claimed |
| EP-2292625-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2013-12-25 | — | — | EP | disclosed |
| EP-2292625-A1 | Substituted spiro compounds and their use for producing pain-relief medicaments | Grünenthal GmbH (DE) | 2011-03-09 | — | — | EP | disclosed |