E-Flupentixol

E-Flupentixol

SCHEMBL145726

OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP3A4 P08684 7/20 1.00
▸ USP2 O75604 6/20 1.00
▸ SIGMAR1 Q99720 5/20 1.00
▸ CYP2D6 P10635 5/20 1.00
▸ MAPK1 P28482 5/20 1.00
▸ TP53 P04637 5/20 1.00
▸ CYP1A2 P05177 4/20 1.00
▸ NFKB1 P19838 4/20 1.00
▸ CYP2C19 P33261 3/20 1.00
▸ THPO P40225 3/20 1.00
▸ TSHR P16473 3/20 1.00
▸ KCNK2 O95069 2/20 1.00
▸ LMNA P02545 8/20 0.98
▸ MEN1 O00255 7/20 0.98
▸ KMT2A Q03164 7/20 0.98
▸ RAD52 P43351 3/20 0.98
▸ GMNN O75496 3/20 0.98
▸ PMP22 Q01453 3/20 0.98
▸ TDP1 Q9NUW8 3/20 0.98
▸ HTR1A P08908 4/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Z-Flupentixol SCHEMBL34200 1.00 CYP3A4 (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
E-Flupentixol SCHEMBL30596168 1.00 CYP3A4 (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
E-Flupentixol SCHEMBL29598791 1.00 CYP3A4 (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
Z-Flupentixol SCHEMBL29361845 1.00 CYP3A4 (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
E-Flupentixol SCHEMBL414352 1.00 CYP3A4 (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
Z-Flupentixol SCHEMBL29620416 1.00 CYP3A4 (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
Z-Flupentixol SCHEMBL1153162 0.99 LMNA (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
E-Flupentixol SCHEMBL11427109 0.99 LMNA (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
E-Flupentixol SCHEMBL1230220 0.99 LMNA (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
Z-Flupentixol SCHEMBL719323 0.99 LMNA (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5289 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 — — WO claimed
US-12550885-B2 Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells UNIVERSITY OF CINCINNATI (US) 2026-02-17 — — US claimed
US-12527754-B2 Methods and compositions for preventing and treating metabolic syndrome induced by antipsychotic treatment and related diseases and conditions TUFTS MEDICAL CENTER, INC. (US) 2026-01-20 — — US claimed
EP-4654963-A1 TREATMENT OF MENTAL ILLNESS VIA ADMINISTRATION OF BUNTANETAP AND ANALOGUES THEREOF Annovis Bio, Inc. (US) 2025-12-03 — — EP claimed
US-20250295674-A1 NEUROACTIVE STEROIDS FOR TREATMENT OF CNS-RELATED DISORDERS SAGE THERAPEUTICS, INC. 2025-09-25 — — US claimed
EP-4618973-A1 METHODS OF SWITCHING NEUROPSYCHIATRIC MEDICATIONS USING ULOTARONT Sumitomo Pharma America, Inc. (US) 2025-09-24 — — EP claimed
US-20250238922-A1 MACHINE-LEARNING SYSTEM FOR DIAGNOSING DISORDERS AND DISEASES AND DETERMINING DRUG RESPONSIVENESS Sanford Burnham Prebys Medical Discovery Institute 2025-07-24 — — US claimed
US-20250213647-A1 CHEMOKINE RECEPTORS AND ALPHA1 ADRENERGIC RECEPTORS/VASOPRESSIN RECEPTORS 1A HETEROMERS AS DRUG TARGETS FOR DISEASE UNIVERSITY OF SOUTH FLORIDA 2025-07-03 — — US claimed
US-20250177418-A1 NEUROACTIVE STEROIDS FOR TREATMENT OF GASTROINTESTINAL DISEASES OR CONDITIONS SAGE THERAPEUTICS, INC. 2025-06-05 — — US claimed
US-20250179064-A1 BENZOQUINOLONE INHIBITORS OF VMAT2 AUSPEX PHARMACEUTICALS LLC 2025-06-05 — — US claimed
CN-1215322-A Method for encapsulating caplets in capsules and solid dosage forms obtainable by this method WARNER LAMBERT CO (US) 1999-04-28 — — CN claimed
EP-0891180-A1 PROCESS FOR ENCAPSULATION OF CAPLETS IN A CAPSULE AND SOLID DOSAGE FORMS OBTAINABLE BY SUCH PROCESS WARNER-LAMBERT COMPANY (US) 1999-01-20 — — EP claimed
WO-1998018610-A1 EMBEDDING AND ENCAPSULATION OF CONTROLLED RELEASE PARTICLES LENGERICH BERNHARD H VAN (US) 1998-05-07 — — WO claimed
CN-1170346-A Process for encapsulation of caplets in capsule and solid dasage forms obtainable by such process WARNER LAMBERT CO (US) 1998-01-14 — — CN claimed
WO-1998000159-A1 USEFUL FORMULATIONS OF ACID ADDITION SALT DRUGS OXIGENE, INC. (US) 1998-01-08 — — WO claimed
WO-1997037629-A1 PROCESS FOR ENCAPSULATION OF CAPLETS IN A CAPSULE AND SOLID DOSAGE FORMS OBTAINABLE BY SUCH PROCESS WARNER-LAMBERT COMPANY (US) 1997-10-16 — — WO claimed
EP-0797424-A1 PROCESS FOR ENCAPSULATION OF CAPLETS IN A CAPSULE AND SOLID DOSAGE FORMS OBTAINABLE BY SUCH PROCESS WARNER-LAMBERT COMPANY (US) 1997-10-01 — — EP claimed
WO-1996018370-A1 PROCESS FOR ENCAPSULATION OF CAPLETS IN A CAPSULE AND SOLID DOSAGE FORMS OBTAINABLE BY SUCH PROCESS WARNER-LAMBERT COMPANY (US) 1996-06-20 — — WO claimed
EP-0428754-B1 HAIR GROWTH STIMULANT SHISEIDO CO LTD (JP) 1994-05-25 — — EP claimed
EP-0428754-A1 HAIR GROWTH STIMULANT SHISEIDO COMPANY LIMITED (JP) 1991-05-29 — — EP claimed
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