Z-Flupentixol

Z-Flupentixol

SCHEMBL34200

OCCN1CCN(CC/C=C2/c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 7/20 1.00
USP2 O75604 6/20 1.00
SIGMAR1 Q99720 5/20 1.00
CYP2D6 P10635 5/20 1.00
MAPK1 P28482 5/20 1.00
TP53 P04637 5/20 1.00
CYP1A2 P05177 4/20 1.00
NFKB1 P19838 4/20 1.00
CYP2C19 P33261 3/20 1.00
THPO P40225 3/20 1.00
TSHR P16473 3/20 1.00
KCNK2 O95069 2/20 1.00
LMNA P02545 8/20 0.98
MEN1 O00255 7/20 0.98
KMT2A Q03164 7/20 0.98
RAD52 P43351 3/20 0.98
GMNN O75496 3/20 0.98
PMP22 Q01453 3/20 0.98
TDP1 Q9NUW8 3/20 0.98
HTR1A P08908 4/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
E-Flupentixol SCHEMBL30596168 1.00 CYP3A4 (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
E-Flupentixol SCHEMBL145726 1.00 CYP3A4 (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
E-Flupentixol SCHEMBL29598791 1.00 CYP3A4 (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
Z-Flupentixol SCHEMBL29361845 1.00 CYP3A4 (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
E-Flupentixol SCHEMBL414352 1.00 CYP3A4 (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
Z-Flupentixol SCHEMBL29620416 1.00 CYP3A4 (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
E-Flupentixol SCHEMBL11427109 0.99 LMNA (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
Z-Flupentixol SCHEMBL719323 0.99 LMNA (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
E-Flupentixol SCHEMBL1230220 0.99 LMNA (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1
Z-Flupentixol SCHEMBL1153162 0.99 LMNA (1.00) CYP3A4USP2SIGMAR1CYP2D6MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8388 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 WO claimed
US-12550885-B2 Red blood cell storage solutions, solution additives, and methods for improving the storage of red blood cells UNIVERSITY OF CINCINNATI (US) 2026-02-17 US claimed
US-12527754-B2 Methods and compositions for preventing and treating metabolic syndrome induced by antipsychotic treatment and related diseases and conditions TUFTS MEDICAL CENTER, INC. (US) 2026-01-20 US claimed
EP-4654963-A1 TREATMENT OF MENTAL ILLNESS VIA ADMINISTRATION OF BUNTANETAP AND ANALOGUES THEREOF Annovis Bio, Inc. (US) 2025-12-03 EP claimed
US-20250295674-A1 NEUROACTIVE STEROIDS FOR TREATMENT OF CNS-RELATED DISORDERS SAGE THERAPEUTICS, INC. 2025-09-25 US claimed
EP-4618973-A1 METHODS OF SWITCHING NEUROPSYCHIATRIC MEDICATIONS USING ULOTARONT Sumitomo Pharma America, Inc. (US) 2025-09-24 EP claimed
US-20250238922-A1 MACHINE-LEARNING SYSTEM FOR DIAGNOSING DISORDERS AND DISEASES AND DETERMINING DRUG RESPONSIVENESS Sanford Burnham Prebys Medical Discovery Institute 2025-07-24 US claimed
US-20250213647-A1 CHEMOKINE RECEPTORS AND ALPHA1 ADRENERGIC RECEPTORS/VASOPRESSIN RECEPTORS 1A HETEROMERS AS DRUG TARGETS FOR DISEASE UNIVERSITY OF SOUTH FLORIDA 2025-07-03 US claimed
US-20250179064-A1 BENZOQUINOLONE INHIBITORS OF VMAT2 AUSPEX PHARMACEUTICALS LLC 2025-06-05 US claimed
US-20250177418-A1 NEUROACTIVE STEROIDS FOR TREATMENT OF GASTROINTESTINAL DISEASES OR CONDITIONS SAGE THERAPEUTICS, INC. 2025-06-05 US claimed
WO-1987001036-A1 ANTICONVULSANT COMPOSITIONS AND METHOD NEW YORK UNIVERSITY (US) 1987-02-26 WO claimed
US-4594357-A Depot antiinflammatory agents TROPONWERKE GMBH & CO. (DE) 1986-06-10 US claimed
EP-0089948-B1 PHARMACEUTICAL COMPOSITIONS COPPEN, Alec James (GB) 1985-08-14 EP claimed
EP-0131790-A2 Etofenamate preparation Troponwerke GmbH & Co. KG (DE) 1985-01-23 EP claimed
EP-0130514-A2 Depot antiphlogistics Troponwerke GmbH & Co. KG (DE) 1985-01-09 EP claimed
EP-0130516-A2 Etofenamate preparation Troponwerke GmbH & Co. KG (DE) 1985-01-09 EP claimed
EP-0130524-A2 Depot antiphlogistics Troponwerke GmbH & Co. KG (DE) 1985-01-09 EP claimed
US-4430435-A MIXING DOPAMINE RECEPTOR MATERIAL, RADIOALTIVE LABELED BINDER, PHOSPHATE BLOCKING AGENT AND MEASUREMENT OF RADIOACTIVITY BURROUGHS WELLCOME CO. (US) 1984-02-07 US claimed
US-4232021-A TRANS-9-(3-(4-HYDROXYETHYL-1-PIPERAZINYL)-PROPYLIDENE)-2 -TRIFLUOROMETHYLTHIAXANTHENE KEFALAS A/S (DK) 1980-11-04 US claimed
US-4197288-A Neuroleptic radioreceptor assay method and kit BURROUGHS WELLCOME CO. (US) 1980-04-08 US claimed