Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 2/20 | 0.42 |
| ▸ | TTK | P33981 | 10/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14573305 | 0.83 | KDM4E (0.55) | TTKFLT3KDM4E | |
| SCHEMBL5618420 | 0.82 | FLT3 (0.46) | TTKMMP13FLT3 | |
| SCHEMBL5618652 | 0.81 | SYK (0.50) | TTKMEN1KMT2AFLT3KDM4E | |
| SCHEMBL5618409 | 0.81 | MMP13 (0.57) | HRH3MMP2MMP13MMP14KDM4E | |
| SCHEMBL5619095 | 0.76 | FLT3 (0.49) | HRH3FLT3 | |
| SCHEMBL14573306 | 0.75 | AKT3 (0.44) | TTKFLT3CAMK2D | |
| SCHEMBL5619126 | 0.73 | SCN9A (0.46) | TTKFLT3 | |
| SCHEMBL13456154 | 0.71 | HDAC1 (0.60) | HRH4HRH3HTR2CKDM4E | |
| SCHEMBL5618954 | 0.70 | FLT3 (0.51) | TTKFLT3 | |
| SCHEMBL5618106 | 0.70 | TTK (0.56) | TTKFLT3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186832-B2 | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors | SUGEN INC. (US) | 2007-03-06 | — | — | US | disclosed |