Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16479477 | 0.85 | TP53 (0.50) | ALDH1A1TP53PTGS2MGLLL3MBTL1 | |
| SCHEMBL12333052 | 0.84 | GSK3A (0.42) | ALDH1A1L3MBTL1 | |
| SCHEMBL16479476 | 0.84 | TRPV1 (0.43) | ALDH1A1TP53PTGS2POLBL3MBTL1 | |
| SCHEMBL10305669 | 0.81 | ALDH1A1 (0.53) | ALDH1A1NPBWR1PTGS1PTGS2MGLL | |
| SCHEMBL13075264 | 0.81 | ALDH1A1 (0.41) | ALDH1A1L3MBTL1 | |
| SCHEMBL18077692 | 0.81 | MAPK14 (0.43) | ALDH1A1TP53L3MBTL1MAOB | |
| SCHEMBL142716 | 0.80 | NPC1 (0.46) | ALDH1A1NOX4PTGS1PTGS2MGLL | |
| SCHEMBL6116854 | 0.78 | KIF11 (0.47) | ALDH1A1PTGS1L3MBTL1MAOB | |
| SCHEMBL142926 | 0.78 | KIF11 (0.47) | ALDH1A1PTGS1PTGS2MGLLPOLB | |
| SCHEMBL10079418 | 0.78 | KDM4E (0.37) | ALDH1A1POLBL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10010536-B2 | Method of modulating stress-activated protein kinase system | INTERMUNE, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-10010536-B2 | Method of modulating stress-activated protein kinase system | INTERMUNE, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-10010536-B2 | Method of modulating stress-activated protein kinase system | INTERMUNE, INC. (US) | 2018-07-03 | — | — | US | disclosed |
| US-20170095462-A1 | METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | INTERMUNE, INC. | 2017-04-06 | — | — | US | disclosed |
| US-20170095462-A1 | METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | INTERMUNE, INC. | 2017-04-06 | — | — | US | disclosed |
| US-20170095462-A1 | METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | INTERMUNE, INC. | 2017-04-06 | — | — | US | disclosed |
| US-9527816-B2 | Method of modulating stress-activated protein kinase system | INTERMUNE, INC. (US) | 2016-12-27 | — | — | US | disclosed |
| US-9527816-B2 | Method of modulating stress-activated protein kinase system | INTERMUNE, INC. (US) | 2016-12-27 | — | — | US | disclosed |
| US-9527816-B2 | Method of modulating stress-activated protein kinase system | INTERMUNE, INC. (US) | 2016-12-27 | — | — | US | disclosed |
| EP-2591784-B1 | Pyridine-2-one-derivatives as modulators of stress-activated protein kinase system | INTERMUNE INC (US) | 2016-09-14 | — | — | EP | disclosed |
| US-7728013-B2 | Method of modulating stress-activated protein kinase system | INTERMUNE, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-20100029578-A1 | Methods of Treating Atrial Fibrillation with P38 Inhibitor Compounds | INTERMUNE, INC. | 2010-02-04 | — | — | US | disclosed |
| US-20100029578-A1 | Methods of Treating Atrial Fibrillation with P38 Inhibitor Compounds | INTERMUNE, INC. | 2010-02-04 | — | — | US | disclosed |
| CN-101237869-A | Pyridone derivatives for modulating stress-activated protein kinase system | INTERMUNE INC (US) | 2008-08-06 | — | — | CN | disclosed |
| EP-1928454-A2 | PYRIDONE DERIVATIVES FOR MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | Intermune, Inc. (US) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007062167-A9 | METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | INTERMUNE INC (US) | 2007-07-26 | — | — | WO | disclosed |
| WO-2007062167-A2 | METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | INTERMUNE, INC. (US) | 2007-05-31 | — | — | WO | disclosed |
| WO-2007053685-A2 | METHODS OF TREATING ATRIAL FIBRILLATION WITH P38 INHIBITOR COMPOUNDS | INTERMUNE, INC. (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20060270612-A1 | Method of modulating stress-activated protein kinase system | INTERMUNE, INC. | 2006-11-30 | — | — | US | disclosed |
| WO-2006122154-A2 | PYRIDONE DERIVATIVES FOR MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | INTERMUNE, INC. (US) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029578-A1 | Methods of Treating Atrial Fibrillation with P38 Inhibitor Compounds | ATF1, MAPKAPK3, MAPKAPK2 | ALDH1A1 900/4885TP53 3806/4885NOX4 122/4885 |
| US-10010536-B2 | Method of modulating stress-activated protein kinase system | MAPKAPK2, MAP3K6, MAP4K1 | ALDH1A1 3375/4885TP53 945/4885NOX4 1322/4885 |
| US-20170095462-A1 | METHOD OF MODULATING STRESS-ACTIVATED PROTEIN KINASE SYSTEM | MAPKAPK2, MAP3K6, MAP4K1 | ALDH1A1 3375/4885TP53 945/4885NOX4 1322/4885 |
| US-20060270612-A1 | Method of modulating stress-activated protein kinase system | MAPKAPK2, MAP3K6, MAP4K1 | ALDH1A1 3375/4885TP53 945/4885NOX4 1322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.