Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 16/20 | 0.66 |
| ▸ | NOS3 | P29474 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.45 |
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
| ▸ | ESRRG | P62508 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14593839 | 0.90 | HTR7 (0.72) | HTR7 | |
| SCHEMBL14594155 | 0.89 | HTR7 (0.56) | HTR7NOS3NOS1NOS2 | |
| SCHEMBL21671816 | 0.82 | HTR7 (0.64) | HTR7NOS3NOS1NOS2ESRRG | |
| SCHEMBL16479302 | 0.81 | HTR7 (0.46) | HTR7TP53 | |
| SCHEMBL16705820 | 0.81 | HTR7 (0.63) | HTR7NOS3NOS1NOS2ESRRG | |
| SCHEMBL4240678 | 0.80 | ESRRG (0.50) | HTR7NOS3NOS1NOS2ESRRG | |
| SCHEMBL23927918 | 0.79 | HTR7 (0.68) | HTR7 | |
| SCHEMBL215782 | 0.79 | HTR7 (0.56) | HTR7NOS3NOS1NOS2ESRRG | |
| SCHEMBL23927826 | 0.79 | HTR7 (0.63) | HTR7NOS3NOS1NOS2ESRRG | |
| SCHEMBL18856945 | 0.78 | PLG (0.45) | HTR7TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070072898-A1 | Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof | TEIJIN PHARMA LIMITED | 2007-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072898-A1 | Pyrazolo[1,5-a]pyridine derivatives or pharmaceutically acceptable salts thereof | MAPKAPK2, MAP4K2, MAPKAPK5 | HTR7 3940/4885NOS3 3398/4885NOS1 2925/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.